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Improving Pregnancy Outcomes With Progesterone — IPOP  

HIV-1-infection Clinical Trial

Official title:
Z 31702 - Improving Pregnancy Outcomes With Progesterone (IPOP): a Trial of 17-Hydroxyprogesterone Caproate to Reduce Preterm Birth Among Women Receiving Antiretroviral Therapy in Pregnancy

Clinical Trial Summary

This is a phase III, double-masked, placebo-controlled, randomized controlled trial taking place in Zambia.

Clinical Trial Description

Weekly intramuscular injections of 250mg 17-alpha hydroxyprogesterone caproate (17P) or indistinguishable placebo will be randomly allocated in a 1:1 ratio started between 16-24 weeks gestation and administered weekly thereafter until 36 6/7 gestational weeks, stillbirth, or delivery, whichever is sooner. Individual participants will be followed from enrollment (prior to 24 weeks gestation) through 42 days postpartum. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03297216
Study type Interventional
Source University of North Carolina, Chapel Hill
Contact
Status Completed
Phase Phase 3
Start date February 7, 2018
Completion date August 6, 2020
View Details
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