HIV-1 Infection Clinical Trial
Official title:
Effect of Maraviroc (MCV) on the Immunological Recovery of HIV-1 Discordant Patients With CD4 Lymphocyte Counts Below 200 Cells/mm3
Maraviroc is an antiretroviral drug that belongs to the family of the CCR5 coreceptor
inhibitors. It has proven to be effective in increasing CD4 lymphocyte counts in both in
treated and naïve patients, irrespective of the viral load.
The investigators hypothesize that adding Maraviroc to the antiretroviral treatment of
discordant patients, defined as those having CD4 lymphocyte counts below 200 cells /mm3
during the last year, could lead to its immunological recovery.
60 patients will be included in this unicentric, prospective, randomized and stratified
clinical trial. They will be randomized to either continue with its usual high activity
antiretroviral therapy (HAART) treatment or to receive 300 mg of Maraviroc every 12 hours
plus its usual treatment. After 24 weeks, lymphocyte counts will be assessed, as well as
safety, clinical progression, immunological profile of the patients and the potential
benefit of Maraviroc for HIV+ cirrhotic patients.
n/a
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
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