Histiocytosis Clinical Trial
Official title:
Optimization of the Time and Dosage of Vemurafenib in BRAF Positive Juvenile Patients With Refractory Histiocytosis
Prospective, interventional, open, randomized, single-center, non-commercial clinical trial to optimize treatment and dosage of vemurafenib in juvenile patients with histiocytosis resistant to conventional therapy and in whom the BRAF gene mutation has been found.
BRAVO clinical study is part of the POLHISTIO project. The POLHISTIO project is a non-commercial clinical trial aimed at optimizing the diagnosis and treatment of juvenile patients with histiocytosis. The project objectives are defined as follows: 1) to estimate the nature and frequency of mutations in patients with histiocytosis in both tumor tissues and free-circulating DNA; 2) to compare molecular test results with clinical data; 3) to evaluate the diagnostic usefulness of the status of molecular analysis (MRD) as a prognostic factor compared with other recognized factors; 4) in the case of failure of conventional therapy - to modify treatment and to apply targeted treatment, based on molecular status of gene mutation. The project is intended to include patients from all over Poland. ;
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT01049854 -
CD34+Selection for Partially Matched Family or Matched Unrelated Adult Donor Transplant
|
Phase 2 | |
Recruiting |
NCT05915208 -
Histiocytic Disorder Follow-up Study
|
||
Recruiting |
NCT04437381 -
Molecular Targets for the Treatment of Histiocytosis
|
||
Terminated |
NCT01050439 -
Unrelated Donor Transplant for Malignant and Non-Malignant Disorders
|
Phase 2 | |
Active, not recruiting |
NCT00145626 -
HLA-Nonidentical Stem Cell and Natural Killer Cell Transplantation for Children Less the Two Years of Age With Hematologic Malignancies
|
Phase 2 | |
Not yet recruiting |
NCT05803629 -
Characterizing Histiocytosis With 68Ga-FAPI PET/CT
|
N/A | |
Recruiting |
NCT04665674 -
Adult Pulmonary Langerhans Cell Histiocytosis: a National Registry-based Prospective Cohort Study
|
||
Terminated |
NCT02012231 -
Phase I/IIa Study to Evaluate the Safety, PK, PD, and Preliminary Efficacy of PLX8394 in Patients With Advanced Cancers.
|
Phase 1 | |
Completed |
NCT01225718 -
Ceftriaxone in Non-neutropenic Fever
|
N/A | |
Active, not recruiting |
NCT03127709 -
A Study of Memory, Thinking, and Brain Imaging in Adults With Histiocytosis
|
||
Recruiting |
NCT05786924 -
A Study of BDTX-4933 in Patients With KRAS, BRAF and Select RAS/MAPK Mutation-Positive Cancers
|
Phase 1 | |
Recruiting |
NCT04943224 -
Optimization of the Time and Dosage of Trametinib in BRAF Negative Juvenile Patients
|
Phase 2 | |
Recruiting |
NCT04943211 -
Determination of Molecular Status, the Efficacy and Safety of Fluorodeoxyglucose in PET-CT Imaging
|
Phase 3 |