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Clinical Trial Summary

In This experiment, the investigators would like to design a new itch model based on the temporal summation of pruritic stimuli. The hypothesis behind this study (temporal summation) is that two overlapped applications of pruritogens will result in a higher itch sensation compared with a single application.


Clinical Trial Description

Chronic itch affects approximately a fifth of the global population and is associated with substantial negative consequences for the affected individuals. Furthermore, there is a lack of efficient treatment options for chronic itch. In order to mimic a clinical itch condition as presented in patients, the aim of the project is to investigate a new itch model based on the multiple applications of pruritogens (temporal summation). In particular, the purpose is to evaluate if a single application of cowhage/histamine (non-histaminergic and histaminergic itch, respectively) results in a lower itch sensation compared with two overlapped applications of the pruritogens on the same area. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT06328543
Study type Interventional
Source Aalborg University
Contact Silvia Lo Vecchio, PhD
Phone +4521397785
Email slv@hst.aau.dk
Status Not yet recruiting
Phase N/A
Start date July 1, 2024
Completion date December 31, 2026

See also
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Recruiting NCT06081946 - Investigation of the Effects of Sleep Fragmentation on Itch and Pain Sensitivity N/A
Recruiting NCT06154824 - Repetitive Applications of Pruritogens and Effects of a Cutaneous-induced Pain Stimulation on Nonhistaminergic Itch Perception N/A
Completed NCT05131555 - Influence of Endurance Exercise and Histamine Receptors on the Gene Expression in Skeletal Muscle N/A
Not yet recruiting NCT06340438 - Investigate the Relationship Between Catastrophizing and the Perception of Itch Intensity in Healthy Individuals N/A
Recruiting NCT06328530 - Itch Sensation Induced by Simultaneous Application of Pruritogens (Spatial Summation) N/A