Histamine Clinical Trial
Official title:
The Role of Histamine in Muscle Protein Synthesis Following Chronic Resistance Training
Blocking histamine H1/H2 receptors blunts chronic endurance training adaptations. The current study addresses the following research question: "What is the influence of histamine H1 signaling on training adaptations following ten weeks of resistance training in human skeletal muscle." Results from this study will yield more insights into the molecular mechanisms of adaptations to exercise training.
Status | Recruiting |
Enrollment | 50 |
Est. completion date | December 31, 2026 |
Est. primary completion date | December 31, 2026 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Male |
Age group | 18 Years to 45 Years |
Eligibility | Inclusion Criteria: - Male - 18-45 years - Not to medium physically active Exclusion Criteria: - Smoking - Chronic disease - High blood pressure - Supplement or medication intake - Seasonal allergies - Vegetarian / vegan - Resistance trained |
Country | Name | City | State |
---|---|---|---|
Belgium | Department of movement and sports sciences, Ghent University, Belgium | Ghent | Oost-Vlaanderen |
Lead Sponsor | Collaborator |
---|---|
University Ghent | Research Foundation Flanders |
Belgium,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Muscle volume | Change in muscle volume | Before and after the 10 weeks of resistance training | |
Primary | Maximal dynamic strength of leg press, bench press, bicep curl and leg curl | Change in maximal dynamic strength of leg press, bench press, bicep curl and leg curl | Before and after the 10 weeks of resistance training | |
Primary | Muscle fiber hypertrophy in muscle biopsies | Change in muscle fiber hypertrophy in muscle biopsies | Before and after the 10 weeks of resistance training | |
Primary | Matsuda index, to estimate whole body glucose metabolism, will be calculated using an oral glucose tolerance test (OGTT: concentration of glucose and insulin in the blood will be measured before and after drinking 75g glucose) | Change in Matsuda index, to estimate whole body glucose metabolism, will be calculated using an oral glucose tolerance test (OGTT: concentration of glucose and insulin in the blood will be measured before and after drinking 75g glucose) | Before and after the 10 weeks of resistance training | |
Primary | Vascular function measured with a single passive leg movement (sPLM: change in femoral blood flow measured with Doppler ultrasound before and after one passive flexion/extension of the leg) | Change in vascular function with a single passive leg movement (sPLM: change in femoral blood flow measured with Doppler ultrasound before and after one passive flexion/extension of the leg) | Before and after the 10 weeks of resistance training | |
Secondary | Blood pressure (systolic and diastolic) | Chance in Blood pressure (systolic and diastolic) | Before and after the 10 weeks of resistance training | |
Secondary | Resting heart rate | Chance in Resting heart rate | Before and after the 10 weeks of resistance training |
Status | Clinical Trial | Phase | |
---|---|---|---|
Recruiting |
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