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Clinical Trial Details — Status: Recruiting

Administrative data

NCT number NCT06152497
Other study ID # MPSH - ONZ-2023-0027
Secondary ID
Status Recruiting
Phase N/A
First received
Last updated
Start date September 1, 2023
Est. completion date December 31, 2026

Study information

Verified date December 2023
Source University Ghent
Contact Wim Derave, Professor
Phone 92646326
Email wim.derave@ugent.be
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

Blocking histamine H1/H2 receptors blunts chronic endurance training adaptations. The current study addresses the following research question: "What is the influence of histamine H1 signaling on training adaptations following ten weeks of resistance training in human skeletal muscle." Results from this study will yield more insights into the molecular mechanisms of adaptations to exercise training.


Recruitment information / eligibility

Status Recruiting
Enrollment 50
Est. completion date December 31, 2026
Est. primary completion date December 31, 2026
Accepts healthy volunteers Accepts Healthy Volunteers
Gender Male
Age group 18 Years to 45 Years
Eligibility Inclusion Criteria: - Male - 18-45 years - Not to medium physically active Exclusion Criteria: - Smoking - Chronic disease - High blood pressure - Supplement or medication intake - Seasonal allergies - Vegetarian / vegan - Resistance trained

Study Design


Related Conditions & MeSH terms


Intervention

Drug:
Placebo
Oral placebo
H1 blockade: Telfast: 180mg Fexofenadine
H1 blockade: oral blockade with 180mg Fexofenadine
Behavioral:
Resistance training
Resistance training: lower body exercise

Locations

Country Name City State
Belgium Department of movement and sports sciences, Ghent University, Belgium Ghent Oost-Vlaanderen

Sponsors (2)

Lead Sponsor Collaborator
University Ghent Research Foundation Flanders

Country where clinical trial is conducted

Belgium, 

Outcome

Type Measure Description Time frame Safety issue
Primary Muscle volume Change in muscle volume Before and after the 10 weeks of resistance training
Primary Maximal dynamic strength of leg press, bench press, bicep curl and leg curl Change in maximal dynamic strength of leg press, bench press, bicep curl and leg curl Before and after the 10 weeks of resistance training
Primary Muscle fiber hypertrophy in muscle biopsies Change in muscle fiber hypertrophy in muscle biopsies Before and after the 10 weeks of resistance training
Primary Matsuda index, to estimate whole body glucose metabolism, will be calculated using an oral glucose tolerance test (OGTT: concentration of glucose and insulin in the blood will be measured before and after drinking 75g glucose) Change in Matsuda index, to estimate whole body glucose metabolism, will be calculated using an oral glucose tolerance test (OGTT: concentration of glucose and insulin in the blood will be measured before and after drinking 75g glucose) Before and after the 10 weeks of resistance training
Primary Vascular function measured with a single passive leg movement (sPLM: change in femoral blood flow measured with Doppler ultrasound before and after one passive flexion/extension of the leg) Change in vascular function with a single passive leg movement (sPLM: change in femoral blood flow measured with Doppler ultrasound before and after one passive flexion/extension of the leg) Before and after the 10 weeks of resistance training
Secondary Blood pressure (systolic and diastolic) Chance in Blood pressure (systolic and diastolic) Before and after the 10 weeks of resistance training
Secondary Resting heart rate Chance in Resting heart rate Before and after the 10 weeks of resistance training
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