Clinical Trials Logo
  1. Home
  2. High Risk Pregnancy
  3. NCT01355822

Impact of the NO-donor Pentaerythrithyltetrantrate on Perinatal Outcome in High-risk Pregnancies

High Risk Pregnancy Clinical Trial

Official title:
Impact of the NO-donor Pentaerythrithyltetrantrate on Perinatal Outcome in High-risk Pregnancies: a Prospective Randomized Pilot Study

Clinical Trial Summary

Pregnancies resulting in IUGR and also in preeclampsia are strongly associated with typical underlying placental pathology revealing small placentas and maldevelopment of the decidual blood vessels, suggesting under-perfusion from the maternal circulation. Since nitric oxide (NO) donors can improve decreased uteroplacental perfusion without any negative effects on fetal circulation, these may prevent negative pregnancy outcomes in patients at risk.

The aim of this study is to evaluate the effectiveness of the long-lasting NO donor pentarythrithyltetranitrate (PETN) to reduce the likelihood of adverse pregnancy outcomes (intrauterine growth retardation / IUGR, perinatal death, placental abruption, and preterm delivery) in women recognized to be at risk for this outcome by abnormal uterine flow in mid gestation.

Clinical Trial Description

n/a

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Prevention

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01355822
Study type Interventional
Source University of Jena
Contact
Status Completed
Phase Phase 1/Phase 2
Start date April 2002
View Details
See also
  Status Clinical Trial Phase
Completed NCT02627482 - Ambulatory Fetal Heart Rate Monitoring in Small Babies N/A
Active, not recruiting NCT03904979 - Therapeutic Writing to Reduce Stress N/A
Completed NCT02749851 - Placenta Imaging Project
Completed NCT03772080 - Prematurity Education in High Risk Pregnancies N/A
Recruiting NCT06151613 - Continuous Non-invasive Electrophysiological Monitoring in High Risk Pregnancies N/A
Enrolling by invitation NCT05763069 - HOME: Home Monitoring of High-risk Pregnancies
Completed NCT01708746 - Investigation of the Impact of Noninvasive Prenatal Testing for Fetal Aneuploidy on Utilization of Prenatal Diagnostic Procedures and Pregnant Women's Views N/A
Not yet recruiting NCT04173559 - Sleep and Tracking Effects in Pregnancy Study N/A
Recruiting NCT03152058 - IMPACT Study: IMProve Pregnancy in APS With Certolizumab Therapy Phase 2
Not yet recruiting NCT06320054 - Preventing Obstetric Complications With Dietary Intervention N/A
Recruiting NCT03220750 - University Hospital Advanced Age Pregnant Cohort N/A
Not yet recruiting NCT04855513 - Prevention of Pre-eclampsia Using Metformin: a Randomized Control Trial N/A
Recruiting NCT06414655 - Multicenter Prospective Cohort Study of Twin Maternal-Child Dyads in China
Completed NCT03082664 - Negative Pressure Wound Therapy to Prevent Wound Complications Following Cesarean Section in High Risk Patients N/A
Recruiting NCT06279559 - Music Therapy and High-risk Pregnancy N/A
Not yet recruiting NCT05479357 - Carbetocin Versus Oxytocin for Prophylaxis Against Atonic Primary Post-partum Hemorrhage N/A
Recruiting NCT04203082 - Cognitive Behavioral Intervention to Reduce Procedural Anxiety Among Woman With High Risk Pregnancies With Scheduled Cesarean Deliveries N/A
Completed NCT02379351 - Use Of An In-Home Non-Stress Test Device For Remote Fetal Monitoring N/A
Recruiting NCT04783597 - Early Prediction of Preeclampsia Using arteriaL Stiffness in High-risk prEgnancies
Recruiting NCT06130150 - Sexual Function in High-risk Pregnant Women