High-Risk Cancer Clinical Trial
Official title:
Neoadjuvant Chemotherapy With Cabazitaxel in High Risk Prostate Cancer Patients Prior to Radical Prostatectomy
This study is aimed at evaluating the efficacy regarding the response rate and metastasis-free survival time of cabazitaxel as a neoadjuvant treatment in patients with high risk prostate cancer.
Patients will be treated by 6 cycles of Cabazitaxel 25 mg/m2 every three weeks and extended radical prostatectomy and extended pelvic lymphadenectomy 4 weeks after completion of chemotherapy. Multiparametric MRI will be performed at baseline, after 3 cycles and after 6 cycles. If there will be evidence of clinical progression after 3rd cycle, patients can be removed from the study and given local therapy, including radical prostatectomy or external beam radiotherapy, at the discretion of the patient's physicians. If patients have evidence of response, they continue on treatment for a total of 6 cycles. If multiparametric MRI demonstrates stable disease an individual risk-benefit analysis has to be performed with regard to continuing or to stopping the neoadjuvant treatment since the definition stable disease includes patients with ≤ 20% tumour shrinkage or tumour progression ;
Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
Status | Clinical Trial | Phase | |
---|---|---|---|
Not yet recruiting |
NCT06041490 -
Adjuvant Therapy for High-risk Hepatocellular Carcinoma Post Liver Transplantation
|
Phase 2 | |
Recruiting |
NCT03978663 -
Three Fraction Radiation to Induce Immuno-Oncologic Response
|
N/A | |
Withdrawn |
NCT05120622 -
Trial of Local Cystoscopic Injection of Tremelimumab Plus Systemic Durvalumab for High Risk Non-Muscle Invasive Bladder Cancer
|
Phase 1/Phase 2 | |
Recruiting |
NCT05254899 -
Anti-PD-1 Antibody and P-GEMOX Chemotherapy Combined With Radiotherapy in High-risk Early-Stage ENKTL
|
Phase 2 | |
Recruiting |
NCT04947098 -
Prevent Cancer- Greenville
|
||
Recruiting |
NCT06020443 -
Adherence to Lung Cancer Screening by Low-dose Thoracic CT in Haut-Rhin Department, France.
|
N/A | |
Completed |
NCT02308280 -
Nonmyeloablative Allogeneic Stem Cell Transplant Followed by Bortezomib in High-risk Multiple Myeloma Patients
|
Phase 2 | |
Active, not recruiting |
NCT06046625 -
Needs and Preferences of Patients With Head-neck Cutaneous SCC
|
||
Recruiting |
NCT06277050 -
Maintenance Therapy With Toripalimab and Capecitabine Versus Capecitabine Alone in High-risk Nasopharyngeal Carcinoma
|
Phase 3 | |
Completed |
NCT03343249 -
Adjunctive Smart Phone Based Smoking Cessation Treatment
|
N/A | |
Recruiting |
NCT06327568 -
Anal Cancer and/or Precancer Screening: Performance Analysis of the BD Onclarity™ HPV Assay on Anal Specimens
|
||
Recruiting |
NCT04334993 -
Pediatric-type Therapy With Pre-transplant Blinatumomab for HR Patients - Phase II Study
|
Phase 2 | |
Recruiting |
NCT05482880 -
Decisional Conflicts, Health-related QoL and Satisfaction With Care in High-risk cSCC in the Head-neck Region
|
||
Recruiting |
NCT05498272 -
Study of Neoadjuvant PARP Inhibition Followed by Radical Prostatectomy in Patients With Unfavorable Intermediate-Risk or High-Risk Prostate Cancer With BRCA1/2 Gene Alterations
|
Phase 2 | |
Terminated |
NCT01479192 -
Fenretinide in Healthy Young Women at Genetic and Familial Risk
|
Phase 3 | |
Recruiting |
NCT05557487 -
Taiwan Real-world LDCT Screening Behavior and Outcome Research for High Risk Subjects Based on Health Promotion Administration
|
||
Recruiting |
NCT04217356 -
Study of Stem Cell Transplant vs. Non-Transplant Therapies in High-Risk Myelofibrosis
|
||
Recruiting |
NCT04740866 -
Adjuvant Radiotherapy Versus Observation After Radical Cystectomy in High Risk Urothelial Bladder Cancer
|
N/A | |
Recruiting |
NCT04905329 -
A Multicenter Prospective Post-registration Study of Empegfilgrastim to Evaluate Safety and Efficacy in Special Cancer Populations
|
||
Active, not recruiting |
NCT01827137 -
WT1 Analog Peptide Vaccine in Patients With Multiple Myeloma Following Autologous Stem Cell Transplantation
|
N/A |