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NCT03451877 Clinical Trial

TGFB1 And LAMA1 Gene Polymorphisms in High Myopia

High Myopia Clinical Trial

Official title:
TGFB1 and LAMA1 Gene Polymorphisms in Turkish Children With High Myopia

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT03451877
Other study ID # 2013-TIP-097
Secondary ID
Status Completed
Phase N/A
First received February 26, 2018
Last updated March 2, 2018
Start date December 1, 2012
Est. completion date June 1, 2017

Study information
Verified date March 2018
Source Ege University
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

The investigators aimed to investigate TGFB1 and LAMA1 gene polymorphisms in children with high myopia in order to determine the genetic basis of large myopic shifts causing severe visual impairment and complications.

Seventy-four children with high myopia (≥6 diopters [D]; study group) and 77 emmetropic children (±0.5D; control group) were included. Genetic and polymorphism analyses were performed in the Medical Genetics Laboratory using DNA purified from the patients' blood samples.

Recruitment information / eligibility
Status Completed
Enrollment 151
Est. completion date June 1, 2017
Est. primary completion date December 1, 2016
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group 3 Years to 13 Years
Eligibility Inclusion Criteria:

- Patients under the age of 13

- Patients with cycloplegic refraction values =6 D (for study group)

- Emmetropic patients (for control group)

Exclusion Criteria:

- Patients who had additional ocular pathology that may affect refraction (such as glaucoma, cataracts, corneal disease)

- Patients with history of ocular surgery

Study Design

Related Conditions & MeSH terms

Intervention

Genetic:
• TGFB1 AND LAMA1 GENE POLYMORPHISMS
we evaluated polymorphisms in the LAMA1 (rs2089760) and TGFB1 (rs4803455) genes in children younger than 13 years of age with =6 D myopia in an attempt to further elucidate the genetic basis of high myopia.

Locations
Country Name City State
n/a

Sponsors (1)
Lead Sponsor Collaborator
Ege University

Outcome
Type Measure Description Time frame Safety issue
Primary Genetic basis of high myopia evaluated polymorphisms in the LAMA1 (rs2089760) and TGFB1 (rs4803455) genes in children younger than 13 years of age with =6 D myopia 4 years
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