High Grade Glioma Clinical Trial
— HiLoGlioOfficial title:
HiLoGlio Organoid Study: 'A Living Tissue Bank of Patient-Derived Organoids From Glioma Tumors'
Verified date | December 2023 |
Source | Maastricht Radiation Oncology |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational |
There is a high medical need to improve treatment outcome for high-grade and low-grade glioma since no curative treatment is available. To achieve this goal, a broader understanding is needed of the causes of inter-and intratumoral heterogeneity; glioma dedifferentiation and invasion; the major determinants of malignancy and treatment failure in glioma patients. Patient-derived organoid (PDOs) of high-grade gliomas and low-grade gliomas will be used to identify the mechanisms that underlie this malignant behaviour and treatment resistance. This insight may be used to develop patient avatars to simultaneously test multiple new treatment modalities that are predictive for survival and quality of life of glioma patients.
Status | Active, not recruiting |
Enrollment | 50 |
Est. completion date | December 2024 |
Est. primary completion date | December 2024 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years and older |
Eligibility | Inclusion Criteria: - MRI diagnosis of low grade glioma (LGG) or high grade glioma (HGG) - Age 18 years or older - Patient is eligible for a resection of the tumor Exclusion Criteria: - Contra-inidication for neurosurgical resection of the tumor. - Incapacitated patient, unable to give informed consent. |
Country | Name | City | State |
---|---|---|---|
Netherlands | Maastricht Radiation Oncology | Maastricht | Limburg |
Lead Sponsor | Collaborator |
---|---|
Maastricht Radiation Oncology | Maastricht University Medical Center, Ziekenhuis Oost-Limburg, Zuyderland Medisch Centrum |
Netherlands,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Phenotypic, genetic, epigenetic proteomic and transcriptomic profile of the LGG/HGG PDOs | Phenotypic, genetic, epigenetic proteomic and transcriptomic profile of the LGG/HGG PDOs will be performed after establishing PDO and the data will be compared with the phenotypic, genetic, epigenetic, proteomic and transcriptomic profile of the parental tumor. DNA isolated from peripheral blood will be used as normal reference DNA for (epi)genetic profiling. | Baseline tumor resection and blood sampling |
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