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Study of Sonodynamic Therapy in Participants With Recurrent High-Grade Glioma

High Grade Glioma Clinical Trial

Official title:
A Phase 0, First in Human, Open-label Study of Intravenous Aminolevulinic Acid HCl (ALA) and MR-Guided Focused Ultrasound Device (MRgFUS) in Participants With Recurrent High Grade Glioma (HGG)

Clinical Trial Summary

A Phase 0 single center, first in human, open-label study of ascending energy doses of sonodynamic therapy (SDT) utilizing the MRgFUS combined with intravenous ALA to assess safety and efficacy in up to 45 participants with recurrent HGG. Eligible participants who are scheduled for resection will be administered intravenous (IV) aminolevulinic acid HCl (ALA) approximately six to seven (6-7) hours prior to receiving sonodynamic therapy (SDT).

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04559685
Study type Interventional
Source St. Joseph's Hospital and Medical Center, Phoenix
Contact Phase 0 Navigator
Phone 602-406-8605
Email research@ivybraintumorcenter.org
Status Recruiting
Phase Early Phase 1
Start date March 15, 2021
Completion date March 31, 2025
View Details
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