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Clinical Trial Summary

The aim of the DIRECT Study is to establish a robust pipeline to identify those patients with high-grade B cell lymphoma most suitable for novel agent clinical trials based upon genomic subtype and an integrated response evaluation determined early in first-line therapy.


Clinical Trial Description

This will be done by integrating data and samples collected from patients undergoing standard of care treatment for high-grade B cell lymphoma Data will be integrated from 1. Clinical risk factors from the International Prognostic Index (IPI) 2. Up-front genomic subtype based on molecular profiling of diagnostic biopsy 3. Serial ctDNA monitoring during treatment. 4. Radiological response imaging ;


Study Design


Related Conditions & MeSH terms


NCT number NCT04226937
Study type Observational
Source Cambridge University Hospitals NHS Foundation Trust
Contact Silvia Tarantino
Phone +44(0)122325634
Email silvia.tarantino@addenbrookes.nhs.uk
Status Recruiting
Phase
Start date September 17, 2020
Completion date September 1, 2025

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