Hepatitis Clinical Trial
Official title:
Efficacy and Safety of the Albumin Dialysis MARS® Therapy in Patients With Fulminant and Subfulminant Hepatic Failure
The purpose of this study is to improve the survival rate of those patients with acute
fulminant hepatitis through treatment with the MARS® extra-corporal liver-purification
system by:
1. Reducing the number of patients who die before a graft is available
2. Increasing the chances of survival without a liver transplant
3. Reducing the pre- and post-operative mortality in transplant patients
Patients with fulminant or subfulminant hepatitis with either an indication or a relative
contraindication to a liver transplantation, are randomized to two groups:
1. A group treated with the conventional medical intensive treatment (including the
hemodialysis techniques, continuous veno-venous hemofiltration or hemodiafiltration, if
necessary) and the gold standard surgical treatment (liver transplantation) compared to
2. A group receiving, in addition to the conventional medical intensive treatment, albumin
dialysis using the MARS device and the gold standard surgical treatment (liver
transplantation).
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
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