Hepatitis C Clinical Trial
Official title:
Patterns of Resistance-associated Substitutions in Patients With Chronic HCV Infection Following Treatment With Direct Acting Antiviral Agents in the Public Health Setting
Successful treatment of hepatitis C has been reported to be associated with 62-84% reduction
in all-cause mortality (deaths), 68-79% reduction in risk of HCC and 90% reduction in risk of
liver transplantation. The efficacy of NS5A inhibitors for the treatment of patients
chronically infected with hepatitis C virus (HCV) can be affected by the presence of NS5A
resistance-associated substitutions (RASs). Pre-existence of resistance associated
substitutions (RASs) to direct antiviral agents (DAAs) reduces sustained virologic response
(SVR) rates by 3-53% in hepatitis C virus (HCV) genotype 3 infected patients depending on
different predictors and the DAA regimen used. This study will prospectively analyze data
from the MukhMantri Punjab Hepatitis C Relief Fund (MMPHCRF) to determine the posttreatment
prevalence of various NS5A RASs, and their effect on outcomes of treatment with
daclatasvir-sofosbuvir or sofosbuvir-ledipasvirin patients with chronic HCV.
The study aims to assess the prevalence and effect of RASs on sustained virological response
(SVR) rates in patients with treatment failure to a regimen containing sofosbuvir and
ledipasvir/daclatasvir.
n/a
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