Hepatitis C Clinical Trial
Official title:
Hepatitis C Virus Detection in Oral Squamous Cell Carcinoma. (Retrospective-cohort Study)
Compare Hepatiis C Virus (HCV) detection between oral squamous cell carcinoma (OSCC) and normal tissues, to determine the possible relationship between HCV and OSCC.
Patient / Population: Paraffin embedded tissue samples of OSCC. Indicator: OSCC patients
Control: Normal patients Formalin fixed paraffin embedded specimens from blocks retrieved
from the archives of the Oral and Maxillofacial Pathology Department, Faculty of dentistry,
Kasr Alini hospital setting from January 2014 till February 2018. All clinical and
histopathological data from medical reports, will be reviewed and data will be collected
regarding age, sex, tumor location, history of smoking and alcohol consumption, nodal status,
tumor recurrences and histological classification of the patients. The specimens will be
obtained from 2 groups:-
1. OSCC specimens. Histological diagnosis of H&E stained sections will be performed
according to World health organisation (WHO) guidelines by 2 independent pathologists.
2. Normal oral mucosa specimens (control).
outcome: I) Immunohistochemical detection of Hepatitis C core antigen (Hep C cAg) : sc-58144,
santa cruz biotechnology, USA) a mouse monoclonal antibody raised against Hepatitis C virus
will be purchased and used for immunohistochemical staining. Staining procedure using an
automated system Ventana Benchmark. The four µm thick paraffin embedded tissue sections will
be deparaffinized in three changes of xylene then microwaved for antigen retrieval. The
slides will be incubated with primary antibody overnight in the humidity chamber at room
temperature. Then, the slides will be incubated with secondary antibody. The peroxidase
activity will be made visible with diaminobenzidine. Finally, counterstaining will be
obtained using Mayer's hematoxylin.
The immunostained sections will be examined using analyzer computer system (Germany).
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