Hepatitis C, Chronic Clinical Trial
Official title:
Biliverdin Reductase A in Chronic Hepatitis C Virus Infection
In this project, the investigators aim to study the role of biliverdin reductase A (BLVRA) in HCV infected patients prior and during/after standard antiviral therapy in association with viral clearance, disease progression and treatment response and in comparison with healthy subjects.
1. To analyze biliverdin reductase (BLVRA) expression in the liver of HVC infected
patients undergoing liver biopsy followed by standard antiviral treatment
(peg-interferon plus ribavirin combination therapy) and patients with other forms of
liver diseases undergoing liver biopsy as controls.
2. To analyze BLVRA expression in peripheral blood leukocytes (PBL) of therapeutically
naïve HCV patients, during/after standard antiviral therapy and healthy controls.
3. To analyze BVLRA genetic polymorphisms both in HCV infected patients and healthy
controls.
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Observational Model: Case Control, Time Perspective: Prospective
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