Hepatitis B Clinical Trial
Official title:
Granulocyte Colony-stimulating Factor(G-CSF) in the Treatment of Hepatic Failure: a Prospective Randomized Controlled Clinical Study
This study evaluates the Granulocyte colony-stimulating factor (G-CSF) in the treatment of Acute on Chronic Liver Failure in adult. Half participants will receive G-CSF and standard treatment in combination, while half participants will receive standard treatment.
Granulocyte colony-stimulating factor (G-CSF) can be used to mobilize stem cells to the
periphery and the liver tissue in patients with advanced liver disease, and could promote
hepatic regeneration. Moreover, G-CSF was reported to protect patients from sepsis by
restoring the function of both neutrophils and monocytes. Therefore, G-CSF therapy may be
beneficial for liver regeneration in patients with ACLF induced by different causes.
standard therapy for the treatment of ACLF includes reduced glutathione, glycyrrhizin,
ademetionine,polyene phosphatidylcholine, alprostadil, and human serum albumin) on the day
of admission. HBV associated ACLF patients receive entecavir at the same time
;
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
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