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Assessment of Hepatitis B Virus Intra-host Population and Host-specific Immune Marker Diversity

Hepatitis B Clinical Trial

Official title:
Assessment of Hepatitis B Virus Intra-host Population and Host-specific Immune Marker Diversity With Next-generation Sequencing: From Chronic Infection to End-stage Liver Disease and Liver Cancer

Clinical Trial Summary

In this project proposal, the investigators will investigate the genetic alterations of Hepatitis B Virus (HBV) strains circulating in Belgian patients who developed end stage liver disease. Additionally, the investigators will compare and link these data sets with three genetic factors involved in immune system response.

Clinical Trial Description

This project proposes to identify and characterize the genetic alterations associated with intra-host evolution of HBV from a chronically infection status to an end-stage liver disease status. ;

Study Design

Time Perspective: Prospective

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02148562
Study type Observational
Source Universitaire Ziekenhuizen Leuven
Contact
Status Enrolling by invitation
Phase N/A
Start date April 2014
Completion date December 2017
View Details
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