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NCT00155103 Clinical Trial

Effect of Polymorphisms in the IL-1 Gene Complex on the Development of Chronic Hepatitis and Hepatocellular Carcinoma

Hepatitis B Clinical Trial

Official title:
Effect of Polymorphisms in the IL-1 Gene Complex on the Development of Chronic Hepatitis and Hepatocellular Carcinoma

Clinical Trial Details — Status: Recruiting

Administrative data
NCT number NCT00155103
Other study ID # 9361700927
Secondary ID NSC 93-2314-B-00
Status Recruiting
Phase N/A
First received September 9, 2005
Last updated March 20, 2007
Start date August 2004

Study information
Verified date July 2005
Source National Taiwan University Hospital
Contact Li-Hui Tseng, M.D., Ph.D.
Phone +886-2-2312-3456
Email htseng@ha.mc.ntu.edu.tw
Is FDA regulated No
Health authority Taiwan: Department of Health
Study type Observational

Clinical Trial Summary

The purpose of this study is to determine the effect of polymorphisms in the IL-1 gene complex on the development of chronic hepatitis and hepatocellular carcinoma.

Description:

We analyzed single-nucleotide polymorphisms in the genes for interleukin-1a, interleukin-1b, interleukin-1-receptor antagonist, interleukin-1-receptor type I, and interleukin-1-receptor type II in 400 normal control and patients (chronic hepatitis and hepatocellular carcinoma). Genotypes were tested for an association with development of chronic hepatitis and hepatocellular carcinoma by multivariable analysis. A second cohort of 1200 normal control and patients (chronic hepatitis and hepatocellular carcinoma) was independently analyzed for the genotype associations identified in the first cohort.

Recruitment information / eligibility
Status Recruiting
Enrollment 1600
Est. completion date
Est. primary completion date
Accepts healthy volunteers Accepts Healthy Volunteers
Gender Both
Age group 18 Years and older
Eligibility Inclusion Criteria:

- Normal controls

- Cases of chronic hepatitis and hepatocellular carcinoma

Exclusion Criteria:

- Pregnant women

Study Design

Observational Model: Case Control, Time Perspective: Longitudinal

Related Conditions & MeSH terms

Locations
Country Name City State
Taiwan Department of Medical Genetics; National Taiwan University Hospital Taipei

Sponsors (2)
Lead Sponsor Collaborator
National Taiwan University Hospital National Science Council, Taiwan

Country where clinical trial is conducted

Taiwan, 

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