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Research on Optimal Immunization Strategy of Hepatitis B Vaccine in Chronic Kidney Disease Population

Hepatitis B Vaccine Clinical Trial

Official title:
Research on Optimal Immunization Strategy of Hepatitis B Vaccine in Chronic Kidney Disease Population

Clinical Trial Summary

At present, chronic kidney disease population are vaccinated with hepatitis B vaccine according to the standard three-dose schedule immunization program, and the effect of preventing HBV infection is not ideal.

This is a randomized, controlled trial. The study will evaluate the immunogenicity and persistence of 20 µg and 60 µg recombinant hepatitis B vaccine with three or four injections at months 0, 1, and 6 or 0, 1, 2, and 6 in chronic kidney disease population.

Clinical Trial Description

Participants are randomized in a ratio of 1:1:1 into 20 µg recombinant hepatitis B vaccine group at months 0, 1, and 6 or 20µg recombinant hepatitis B vaccine group at months 0, 1, 2, and 6 or 60µg recombinant hepatitis B vaccine group at months 0, 1, 2, and 6. HBsAg and anti-HBs will be tested during the study period. Adverse reactions will be recorded after vaccination. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03962881
Study type Interventional
Source Shanxi Medical University
Contact Yongliang Feng, PhD
Phone #86-351-4135362
Email fengyongliang048@163.com
Status Not yet recruiting
Phase Phase 4
Start date May 25, 2019
Completion date December 2023
View Details
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