Hepatitis B Vaccine Clinical Trial
Official title:
A Prospective Study on the Immunogenicity and Persistence of Hepatitis B Vaccine in Methadone Maintenance Treatment Patients
At present, Methadone Maintenance Treatment Patients of Hepatitis B Vaccination in are
vaccinated with hepatitis B vaccine according to the standard three-dose schedule
immunization program, and the effect of preventing HBV infection is not ideal.
This is a randomized, controlled trial. The study will evaluate the immunogenicity and
persistence of 20 µg and 60 µg recombinant hepatitis B vaccine with three or four injections
at months 0, 1, and 6 or 0, 1,2, and 6 in Methadone Maintenance Treatment Patients
Participants are randomized in a ratio of 1:1:1 into 20 µg recombinant hepatitis B vaccine group at months 0, 1, and 6 or 20µg recombinant hepatitis B vaccine group at months 0, 1, 2, and 6 or 60µg recombinant hepatitis B vaccine group at months 0, 1, 2, and 6. HBsAg and anti-HBs will be tested during the study period. Adverse reactions will be recorded after vaccination. ;
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