Hepatitis A Clinical Trial
Official title:
Hepatitis A Vaccination in the Elderly
A lot of elderly people travel to hepatitis A endemic areas. The prevalence of hepatitis A
IgG positivity is declining in the Netherlands, also in the elderly. Studies show that
people above 40 years of age have a slower immune response to hepatitis A vaccination.
However, a lot of travelers seek pre-travel advice only shortly before their journey. More
information about the time to adequate antibody response after hepatitis A vaccination is
required to provide good protection during travelling. Alternative protection with
immunoglobulins are available.
Study design: Observational, longitudinal pilot study Study population: 20 adults over 60
years of age with a negative hepatitis A IgG, (with a estimated 50% positivity for hepatitis
A IgG in this age Group, 40 patients in this age group) 20 adults 18-40 years of age as
controls.
Intervention (if applicable): When hepatitis A vaccination is indicated and informed consent
is obtained, hepatitis A IgG wil be measured at day 0, 7, 14, 21 en 28.
Main study parameters/endpoints: Time to protective hepatitis A IgG. Nature and extent of
the burden and risks associated with participation, benefit and group relatedness: hepatitis
A vaccination will be given also outside this study. In the study 5 venous punctures of 7 ml
of blood.
n/a
Observational Model: Cohort, Time Perspective: Prospective
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