Hepatic Steatosis Clinical Trial
Official title:
Effects of Coffees With Various Compositions of Antioxidants on Hepatic Steatosis Induced by a High Fructose, Hypercaloric Diet
This study will assess
- whether coffee consumption protects against fructose-induced hepatic steatosis in
healthy humans
- whether the protective effect of coffee is dependent on it's antioxidant composition
Epidemiological studies suggest that coffee consumption improves glucose homeostasis in
insulin resistant subjects. An increase in intrahepatic lipids (hepatic steatosis) is highly
prevalent in patients with the metabolic syndrome and may be used as a marker of altered
hepatic lipid metabolism. Such an increased hepatic lipids content can be experimentally
produced in healthy humans by a 6-day high fructose diet.
The purpose of this study is to evaluate whether coffee prevents hepatic lipid deposition in
healthy male subjects fed a fructose-rich hypercaloric diet. Both caffeine and antioxidants
(yet unspecified) may be involved.. To sort out the role of caffeine and antioxidants, we
will test 3 different soluble coffee, ie fully torrefied decaffeinated coffee , partially
torrefied decaffeinated coffee, and partially torrefied caffeinated coffee.
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Factorial Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Prevention
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