Hepatic Impairment Clinical Trial
Official title:
A Phase I, Parallel-group, Multi-center, Open-label, Investigation of the Pharmacokinetics, Safety and Tolerability of a Single Subcutaneous Injection of Cotadutide in Participants With Mild, Moderate or Severe Hepatic Impairment Compared to Participants With Normal Hepatic Function
This study will assess the pharmacokinetics (PK), safety, and tolerability of a single subcutaneous injection of cotadutide in participants with mild, moderate or severe hepatic impairment compared to participants with normal hepatic function.
This study will consist of four cohorts (Cohort 1, Cohort 2, Cohort 3, and Cohort 4). Participants will be assigned to each of the cohorts as per Child-Pugh classification: - Cohort 1: Mild hepatic impairment (Child-Pugh A), cotadutide 50 μg - Cohort 2: Moderate hepatic impairment (Child-Pugh B), cotadutide 50 μg - Cohort 3: Severe hepatic impairment (Child-Pugh C), cotadutide 50 μg - Cohort 4: Normal hepatic function, cotadutide 50 μg ;
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