Hepatic Blood Flow Changes During Fluid Challenge Assessed by MRI in Volunteers Subjects.

Hepatic Flow Changes Clinical Trial

— PORTEAU  

Official title:

Hepatic Blood Flow Changes During Fluid Challenge Assessed by MRI in Volunteers Subjects: a Prospective Monocentric Study. PORTEAU Trial

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03589261
• Other study ID #: PI2018_843_0006
• Status: Completed
• Phase: N/A
• Start date: September 6, 2018
• Est. completion date: March 29, 2019

Study information

• Verified date: April 2019
• Source: Centre Hospitalier Universitaire, Amiens
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Hepatic artery and portal flows are both regulated to assume the whole hepatic blood flow. Each counts for respectively 25% and 75%. That so-called "buffer response" assumes that when portal flow increases, hepatic artery flow decreases. During fluid challenge in intensive care unit, fluid challenge is often administered to improve hepatic perfusion. That observation is not demonstrated. The aim of the study is to test buffer response and portal flow during fluid challenge.

Description:

Prospective monocentric study at Amiens Hospital University. 20 volunteers subjects will be include after providing informed consent. Fluid challenge will be performed with 500 ml of intra venous NaCl (0.9%). Hepatic blood flow measurement will be performed using MRI.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 22
• Est. completion date: March 29, 2019
• Est. primary completion date: March 29, 2019
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 30 Years

Eligibility

Inclusion Criteria:

• Fasting for the last 12 hours.

Exclusion Criteria:

• Claustrophobia

• Any previous medical history disease;

• Any abdominal surgical disease

• Pregnancy or breastfeeding

Related Conditions & MeSH terms

• Hepatic Flow Changes

Intervention

Device:
• MRI (magnetic resonance imaging)
Fluid challenge will be performed with 500 ml of intra venous NaCl (0.9%). Hepatic blood flow measurement will be performed using MRI.

Locations

Country	Name	City	State
France	CHU Amiens-Picardie	Amiens

Sponsors (1)

Lead Sponsor	Collaborator
Centre Hospitalier Universitaire, Amiens

Country where clinical trial is conducted

France, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Other	Flow ratio of portal flow on hepatic artery flow	Flow ratio of portal flow on hepatic artery flow before and after a volume expansion of 500 ml NaCl 0.9%.	Two hours
Primary	Portal blood flow measure before and after fluid challenge	Fluid challenge will be performed with 500 ml of intra venous NaCl (0.9%). Hepatic blood flow measurement will be performed using MRI (magnetic resonance imaging).	Two hours: the difference in hepatic portal flow before and after a volume expansion of 500 ml NaCl 0.9%.
Secondary	Hepatic artery blood flow measure before and after fluid challenge	Hepatic artery blood flow measure before and after a volume expansion of 500 ml NaCl 0.9%.	Two hours