Hepatic Encephalopathy Clinical Trial
Minimal hepatic encephalopathy (MHE) has a negative effect on patients’ daily functioning.
No study has so far investigated the effect of treatment related improvement in cognitive
functions on health related quality-of-life (HRQOL). This study was carried out to determine
the influence of treatment on psychomotor performance and on HRQOL in patients with MHE.
The mean number of abnormal NP tests decreased significantly in patients in treated group
compared with patients in untreated group MANOVA for time and treatment, P =.001). Mean
total SIP score improved among patients in the treated group after 3 months compared with
patients in untreated group after 3 months (MANOVA for time and treatment, P=.002).
Improvement in HRQOL was related to the improvement in psychometry. In conclusion, treatment
with lactulose improves both cognitive functions and HRQOL in cirrhotic patients with MHE.
The study has been published in March 2007 in Hepatology
Lactulose Improves Cognitive Functions and Health-Related Quality of Life in Patients with
Cirrhosis WhoHave Minimal Hepatic Encephalopathy.Srinivasa Prasad, Radha K. Dhiman, Ajay
Duseja, Yogesh K. Chawla, Arpita Sharma, and Ritesh Agarwal. (HEPATOLOGY 2007;45:549-559.)
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
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