Heparin-Induced Thrombocytopenia Clinical Trial
Official title:
Heparin Antibodies in Intensive Care Unit Patients (HAICU)
Intensive care unit patients have multiple risk factors for venous thromboembolism. Venous
thromboembolism leads to significant morbidity and can be fatal. Unfractionated heparin and
low molecular weight heparin are commonly used to prevent venous thromboembolism. Heparin
induced thrombocytopenia, an untoward consequence of exposure to heparin, is an immune
disorder that may develop in patients treated with heparin products. Determining the
prevalence of heparin induced thrombocytopenia and its relationship to preventive and
therapeutic heparin and low molecular weight heparin will help clinicians more appropriately
choose methods of venous thromboembolism prophylaxis and treatment in the critically ill,
ICU population.
The objective of this study is to determine the prevalence of heparin-induced antibodies on
admission to the ICU and the development of new heparin-antibodies during the first week of
hospitalization.
Status | Completed |
Enrollment | 185 |
Est. completion date | May 2006 |
Est. primary completion date | |
Accepts healthy volunteers | No |
Gender | Both |
Age group | 18 Years and older |
Eligibility |
Inclusion Criteria: - Adult patients (> 18 years of age) admitted to the - Neuro-trauma intensive care unit (NTICU) - Shock-trauma intensive care unit (STICU) or - Medical intensive care unit (MICU). - Completed informed consent process. Exclusion Criteria: - Admitted to ICU for short-term observation or expected hospital length of stay of less than 5 days - Undergoing or planned plasmaphoresis |
Observational Model: Cohort, Time Perspective: Prospective
Country | Name | City | State |
---|---|---|---|
United States | UT-Houston/Memorial Hermann Hospital | Houston | Texas |
United States | Florida Hospital Center for Hemostasis & Thrombosis (Laboratory) | Orlando | Florida |
Lead Sponsor | Collaborator |
---|---|
The University of Texas Health Science Center, Houston | GlaxoSmithKline |
United States,
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