Clinical Trials Logo
  1. Home
  2. Hemorrhagic Stroke
  3. NCT03743103

Esmolol for the Treatment of Hypertension After Intracerebral Hemorrhage Study (ETHICHS) — ETHICHS  

Hemorrhagic Stroke Clinical Trial

Official title:
A Randomized, Exploratory, Open-label, Phase IV, Blinded Endpoint, Multicenter and Prospective Study to Evaluate the Effect of the Addition of Esmolol on the Current Therapeutic Regimen Used for the Treatment of Hemorrhagic Stroke

Clinical Trial Summary

Because of its pharmacokinetic characteristics, such as short half-life and its safety profile, esmolol hydrochloride is a beta blocker suitable for venous use in the form of continuous infusion. Strategies that improve the blood pressure control of patients with hemorrhagic stroke during the first hours of hospitalization are determinant in controlling the hematoma expansion and determining factor in its prognosis. This study was designed with the objective of evaluating the beneficial effects of combining esmolol hydrochloride with sodium nitroprusside for the blood pressure control of participants with hemorrhagic stroke.

Clinical Trial Description

Participants with parenchymal intracranial hemorrhage (diagnosis confirmed by computed tomography or magnetic resonance imaging), and: - with systolic pressure > 150 mmHg, - not contraindicated for treatment with beta-blockers, - who can start the drug treatment within 6 hours of the stroke, - having a target of ≤ 140 mmHg of systolic pressure within 1 hour after initiation of treatment. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03743103
Study type Interventional
Source Cristália Produtos Químicos Farmacêuticos Ltda.
Contact
Status Terminated
Phase Phase 4
Start date April 18, 2019
Completion date October 31, 2021
View Details
See also
  Status Clinical Trial Phase
Completed NCT03281590 - Stroke and Cerebrovascular Diseases Registry
Not yet recruiting NCT06026696 - Cohort of Neurovascular Diseases Treated in the Acute Phase and Followed at Lariboisière
Completed NCT01573117 - A Randomized Trial Comparing 2 Methods for Rapid Induction of Cooling in Stroke Patients, Cold Infusions vs. RhinoChill (iCOOL 1) Phase 2
Completed NCT03292211 - The Effect of Early Mobilization in Mild to Moderate Hemorrhagic Stroke N/A
Not yet recruiting NCT06069973 - Using Machine Learning and Biomarkers for Early Detection of Delayed Cerebral Ischemia
Not yet recruiting NCT05816213 - Point-of-care Low-field MRI in Acute Stroke
Not yet recruiting NCT05502874 - Multicenter Registry for Assessment of Markers of Early Neurological Deterioration in Primary Intracerebral Hemorrhage
Recruiting NCT04534556 - Wireless Nerve Stimulation Device To Enhance Recovery After Stroke N/A
Recruiting NCT04200781 - Clinical Evaluation of Shengdi Dahuang Decoction in the Treatment of Acute Hemorrhagic Stroke Phase 4
Recruiting NCT05440682 - Connectivity in Cranioplasty N/A
Completed NCT05121415 - Investigation of Genetic Disease Marker Associated With Spontaneous Haemorrhagic Stroke Complicating Severe Pre-eclampsia in Pregnancy
Terminated NCT02626377 - Multicenter Prospective Cohort of Informal Caregivers in Burgundy and Franche-Comté N/A
Completed NCT01942031 - Improved Prevention of Stroke in Primary Care in Stockholm, Sweden (Förbättrad Prevention av Stroke) N/A
Completed NCT01845350 - Safety of Autologous M2 Macrophage in Treatment of Non-Acute Stroke Patients Phase 1
Recruiting NCT05865795 - Mapping the Natural History of Parenychymal and Cerebral Perfusion Changes in Acute Ischemic and Hemorrhagic Strokes
Completed NCT04612218 - Biomarkers for Initiating Onsite and Faster Ambulance Stroke Therapies
Recruiting NCT06134921 - Effects of Transcranial Electrical Stimulation in Stroke Individuals N/A
Recruiting NCT06190314 - SERUM VITAMIN B12 LEVELS IN PATIENTS WITH HEMORRHAGIC VS ISCHEMIC CEREBROVASCULAR EVENT.
Recruiting NCT05735405 - Aerobic Exercise and Cognitive Training in Patients With Stroke N/A
Recruiting NCT06107725 - Maimonides Minocycline in Stroke Study Phase 2/Phase 3