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Norepinephrine in Preperiod of Hypotensive Resuscitation in Hemorrhagic Shock

Hemorrhagic Shock Clinical Trial

Official title:
Is Low Dose Norepinephrine Effective in Preperiod of Hypotensive Resuscitation in Hemorrhagic Shock?

Clinical Trial Summary

The aim of this work was to investigate the effects of low dose of norepinephrine in preperiod of hypotensive resuscitation in hemorrhagic shock.

Clinical Trial Description

Hemorrhagic shock is one of the leading causes of death following trauma. New fluid resuscitation concepts, including hypotensive, hypothermic, and delayed resuscitation for uncontrolled hemorrhagic shock, have been put forward and obtained a good effect both in clinical and laboratory parameters. The 2019 European guideline on the management of major bleeding and coagulopathy following trauma recommends the use of norepinephrine (NE) for maintaining target arterial blood pressure in patients with life-threatening hypotension. NE has potent α-adrenergic receptor activation activity, which can stimulate α-1 adrenergic receptors on peripheral vascular smooth muscles. High-dose NE may result in excessive arteriolar vasoconstriction which subsequently leads to the disorder of microcirculation and tissue hypoxia. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06311903
Study type Interventional
Source Tanta University
Contact Rabab M Mohamed, MD
Phone 00201069122935
Email rabmoh_30@outlook.com
Status Recruiting
Phase N/A
Start date December 1, 2023
Completion date April 1, 2024
View Details
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