Hemophilia Clinical Trial
Official title:
Prospective and Multicenter Study to Assess the Safety and Effectiveness of a Physiotherapy Treatment Through Fascial Therapy in Hemophilic Elbow Arthropathy. A Pilot Study.
Introduction: The common clinical manifestations of hemophilia are skeletal muscle bleeds,
especially hematomas and hemarthrosis. Repeated episodes of joint bleeding in certain joints,
causing a progressive joint deterioration. Secondary disorders to this joint degeneration
include: biomechanical alterations, loss of range of movement and periarticular muscle
atrophy.
Design. A prospective, multicenter and longitudinal pilot study to evaluate the efficacy of a
treatment protocol with fascial therapy applied in patients with hemophilic arthropathy of
the elbow.
Aimed: To evaluate the safety and efficacy of a physiotherapy treatment by fascial therapy in
patients with hemophilic arthropathy of the elbow Patients: A total of 60 patients with
hemophilia and prophylactic treatment will be recruited for inclusion in the study. Patients
will be recruited in 6 centers, from different regions of Spain.
Intervention: Each session will last approximately 50 minutes, with three physiotherapy
sessions taking place over a period of 3 weeks. The treatment program includes 11 maneuvers
that must be administered bilaterally:
Measuring instruments and study variables: goniometric evaluation (range of movement); visual
analog scale (joint pain); Haemophilia Joint Health Score (joint status); DASH Questionnaire
(functionality of upper limbs); SF-36 Questionnaire (perception of quality of life). At the
same time, the study will allow to determine joint bleeding caused by applied physiotherapy
treatment.
Expected results: First, it is intended to demonstrate the safety of this physiotherapy
technique in patients with hemophilia. Likewise, an improvement in the perception of elbow
pain and joint mobility is expected. An improved functionality of the upper limb is also
foreseen and with it, an enhanced perception of quality of life of these patients.
n/a
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT05617209 -
In Vitro Correction of Thrombin Generation by Concizumab (Anti-TFPI) for Severe Hemophilia Patients
|
||
| Completed |
NCT05039008 -
Restricting Blood Flow in Improving Muscle Strength in Patients With Hemophilic Arthropathy
|
N/A | |
| Recruiting |
NCT04398628 -
ATHN Transcends: A Natural History Study of Non-Neoplastic Hematologic Disorders
|
||
| Completed |
NCT02546622 -
ATHN 2: Factor Switching Study
|
||
| Terminated |
NCT02586012 -
Weight-based Dosing in Hemophilia A
|
Phase 2 | |
| Unknown status |
NCT02433782 -
Myofascial Therapy in Patients With Hemophilic Arthropathy
|
N/A | |
| Completed |
NCT02165462 -
Bilateral Deficit Phenomenon in Patients With Haemophilic Arthropathy
|
N/A | |
| Unknown status |
NCT02165592 -
Assessment of Proprioceptive and Functional Characteristics in Patients With Hemophilia
|
N/A | |
| Completed |
NCT01232634 -
Validation of Ultrasound as a Diagnostic Tool for Assessment of Hemophilic Arthropathy of Knees and Ankles
|
Phase 2 | |
| Completed |
NCT05104164 -
Self-myofascial Release in Hemophilic Ankle Arthropathy
|
N/A | |
| Terminated |
NCT01191372 -
First-in-Human and Proof-of-Mechanism Study of ARC19499 Administered to Hemophilia Patients
|
Phase 1 | |
| Completed |
NCT05173129 -
Posture Analysis for Patients With Haemophilia
|
N/A | |
| Completed |
NCT03818529 -
ATHN 8: Previously Untreated Patients (PUPs) Matter Study
|
||
| Withdrawn |
NCT03996486 -
Study to Test the Safety of an Investigational Drug Given Repeatedly to Adult Men With Severe Hemophilia
|
Phase 1 | |
| Completed |
NCT01708564 -
A Phase I Safety, Pharmacokinetics and Pharmacodynamics Study of Recombinant Factor VIIa in Adult Patients With Hemophilia A or B
|
Phase 1 | |
| Completed |
NCT03842605 -
Efficacy of Strength Training in Improving Elbow Range of Motion and Function in Adults With Hemophilia
|
N/A | |
| Completed |
NCT05549843 -
Manual Therapy in the Treatment of Hemophilic Arthropathy of the Ankle
|
N/A | |
| Recruiting |
NCT06010953 -
SS109 and NovoSeven ® PK / PD Profile, and Preliminary Efficacy and Safety of SS109 on Demand Treatment
|
Phase 1/Phase 2 | |
| Completed |
NCT05027230 -
A Safety and Efficacy Study of STSP-0601 in Adult Patients With Hemophilia A or B With Inhibitor
|
Phase 1/Phase 2 | |
| Not yet recruiting |
NCT06014320 -
Alterations in Coagulation Factor Levels in Patients With End Stage Liver Disease
|