Prospective Biomarkers of Bone Metabolism in Hemophilia A

Status Completed

Clinical Trial Summary

One of the major shortcomings in studying bone disease in hemophilia is the lack of fracture outcome data demonstrating the clinical significance of decreased BMD and altered bone biomarkers in the hemophilia population. This study demonstrates that PwH have an increased risk of fracture compared to the general population and that the issue of bone health will increase in importance as the PwH population ages.

Clinical Trial Description

This is a pilot study to determine the impact of factor replacement on bone biomarkers in up to 20 hemophilia A subjects. Subjects will be recruited over 1 year for the 5-day protocol.

Following a 72-hour washout period, factor levels and bone biomarkers will be followed before and after 50 units/kg replacement on Day 1 and 20 units/kg replacement on Day 3. Each subject can serve as their Figure 4. Fracture rates in PwH compared to historic controls. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT02306694
Study type	Interventional
Source	Oregon Health and Science University
Contact
Status	Completed
Phase	Phase 3
Start date	December 2014
Completion date	April 16, 2018

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