Effect of Exercise in Pediatric Hemophilia

Hemophilia Arthropathy Clinical Trial

Official title: The Effect of Exercise Training on Pain, Physical Activity and Quality of Life in Pediatric Hemophilia Patients

Status Active, not recruiting

Clinical Trial Summary

This study investigates the effect of exercise training on pain, physical activity and quality of life in pediatric hemophilia patients.

Clinical Trial Description

Hemophilia is a congenital X-linked recessive disease characterized by the lack or absence of clotting factors in the blood. Male individuals with problems in the X chromosome are affected, females are carriers. There are two common types, factor VIII (Hemophilia A) and factor IX (Hemophilia B), and the percentage of the exposed factor in circulation determines the degree of hemophilia disease (<1% severe, 1-5% moderate,> 20% mild). The most common clinical symptoms in hemophilia are intra-articular and intramuscular spontaneous bleeding, a history of bleeding that lasts longer than expected after trauma, hemarthrosis and hematomas after crawling or walking in children with moderate or severe hemophilia. Pain, swelling, redness, temperature increase and limitation of movement occur in the bleeding joint. Bleeding into the joint space causes inflammation in the synovial membrane and synovitis occurs. With chronic synovitis, the synovial membrane thickens. Degeneration of the joint cartilage and narrowing of the joint space occurs. Hemarthroses constitute 70-80% of bleeding findings. The most common bleeding joints are knee joints with a rate of 45%. Besides pharmacological treatment for joint and muscle bleeding, the most suitable option is exercise therapy.

The aim of our study is to examine the effect of exercise agitation on pain, physical activity and quality of life in pediatric hemophilia patients. The results of the study indicate that the exercise protocol developed for the lower extremity in pediatric hemophilia patients will have a positive effect on pain, physical activity and quality of life. ;

Related Conditions & MeSH terms

• Hemophilia A
• Hemophilia A, Severe
• Hemophilia Arthropathy
• Joint Diseases

• NCT number: NCT04754997
• Study type: Interventional
• Source: Hasan Kalyoncu University
• Status: Active, not recruiting
• Phase: N/A
• Start date: January 16, 2021
• Completion date: November 30, 2021