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ITI Using SCT800 Alone or Combining Daratumumab in Hemophilia A Adolescents and Adults With High Titer Inhibitor

Hemophilia A With Inhibitor Clinical Trial

Official title:
The Outcome Comparison of Immune Tolerance Induction Therapy Using SCT800 Combined With Daratumumab or SCT800 Alone in Hemophilia A Adolescents and Adults With High Titer Inhibitor: a Non-randomized Controlled Trial

Clinical Trial Summary

To evaluate the time of response, sustained remission rate, and relapse rate of CD38 monoclonal antibody (Daratumumab) combined with SCT800 (rFVIII) in the treatment of hemophilia A adolescents and adults with high titer inhibitors.

Clinical Trial Description

This is a non-randomized controlled trial to compare the outcome of immune tolerance induction therapy usingnon- SCT800 combined with Daratumumab or SCT800 alone in hemophilia A adolescents and adults with high titer inhibitors. Patients will receive Daratumumab combined with SCT800 or SCT800 alone. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05888870
Study type Interventional
Source Institute of Hematology & Blood Diseases Hospital, China
Contact Wei Liu
Phone +8613820261971
Email liuwei1@ihcams.ac.cn
Status Recruiting
Phase Phase 4
Start date November 22, 2023
Completion date December 1, 2026
View Details
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