Hemolysis Clinical Trial
Official title:
Protective Effect of Propofol Against Hemolysis in Patients Submitted to Gastroplasty
Verified date | November 2009 |
Source | Centro Medico Campinas |
Contact | n/a |
Is FDA regulated | No |
Health authority | Brazil: National Committee of Ethics in Research |
Study type | Interventional |
The purpose of this study is to determine if propofol could protect erythrocytes by directly scavenging free radicals from the blood current and increasing resistance of their cell membranes in patients submitted to gastroplasty.
Status | Active, not recruiting |
Enrollment | 60 |
Est. completion date | June 2009 |
Est. primary completion date | May 2009 |
Accepts healthy volunteers | No |
Gender | Both |
Age group | 18 Years to 65 Years |
Eligibility |
Inclusion Criteria: - patients between BMI 40-50 kg/m2 Exclusion Criteria: - patients with BMI under 40 kg/m2 and over 50 kg/m2 - alcohol users - illicit-drug users - patients in regular use of anti-depressants, proton bomb inhibitors or calcium canal blockers - patients transfused either recently, during the intra-operative period or within 10 hours post-operative - patients previously known to be hypersensitive to any drug that is used during the study - patients with any psychiatric disorder or dementia |
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Outcomes Assessor), Primary Purpose: Treatment
Country | Name | City | State |
---|---|---|---|
Brazil | Fundação Centro Médico de Campinas | Campinas | São Paulo |
Lead Sponsor | Collaborator |
---|---|
Centro Medico Campinas |
Brazil,
Tsuchiya M, Asada A, Kasahara E, Sato EF, Shindo M, Inoue M. Antioxidant protection of propofol and its recycling in erythrocyte membranes. Am J Respir Crit Care Med. 2002 Jan 1;165(1):54-60. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Count erythrocytes | After 10 hours post-surgery | Yes | |
Secondary | Bilirubins(direct and indirect) | After 10 hours post-surgery | Yes |
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT03439605 -
Effect of in Vitro Haemolysis on Serum High Sensitivity Troponin T Measurements From Patients in Accident & Emergency
|
N/A | |
Completed |
NCT03434145 -
Changes of Ocular Structures After Hemodialysis in Patients With Chronic Kidney Diseases
|
N/A | |
Completed |
NCT04084301 -
Impact of Cardiopulmonary Bypass Flow on Renal Oxygenation, Blood Flow and Tubular Injury
|
N/A | |
Not yet recruiting |
NCT01201174 -
Hemolysis in Patients With Hereditary Spherocytosis (HS)
|
N/A | |
Completed |
NCT03582592 -
Fluid Distribution Timetable on Adherence to Fluid Restriction of Patients With End-Stage Renal Disease on Hemodialysis
|
N/A | |
Not yet recruiting |
NCT05754294 -
Electric Polarization of Red Blood Cells : A Cohort Study to Assess the Erythrocytes Membrane Integrity Through Charge Conservation, Following Cardiac Surgery.
|
||
Completed |
NCT02996786 -
Effects of Danggui Buxue Tang on Blood Biochemical Parameters in Male Recreational Runners
|
N/A | |
Completed |
NCT02259478 -
Isoagglutinins in the Development of IVIG-associated Hemolysis
|
N/A | |
Not yet recruiting |
NCT05647200 -
Optimization of Prime Fluid Strategy to Preserve Microcirculatory Perfusion During Cardiac Surgery With Cardiopulmonary Bypass, Part II
|
N/A | |
Completed |
NCT05962268 -
The Effect Of Vıdeo-Based Fıstula Care Educatıon On Hemodıalysıs
|
N/A | |
Recruiting |
NCT06223802 -
Biodex Training in Hemodialysis Females With Osteopenia
|
N/A | |
Not yet recruiting |
NCT06096428 -
Hemolysis During Pulsed-field and Radiofrequency Ablation
|
||
Recruiting |
NCT03330223 -
Effect of Haemodialysis on the Efficacy of Antiplatelet Agents
|
N/A | |
Completed |
NCT04203784 -
Meropenem and Piperacillin Plasma Concentrations During CRRT
|
||
Completed |
NCT06215339 -
Diet Therapy in Hemodialysis Patients
|
N/A | |
Recruiting |
NCT05539248 -
A Study on the Safety, Tolerability, Efficacy, Pharmacokinetics and Pharmacodynamics of CAN106 in Subjects With PNH
|
Phase 1/Phase 2 | |
Recruiting |
NCT03633435 -
Home Hemodialysis Assisted by a Nurse for Arterio-venous Fistula Cannulation
|
N/A | |
Withdrawn |
NCT02217683 -
Use of Inhaled Nitric Oxide to Prevent Pulmonary Hypertension Associated to Stored Blood Transfusion
|
Phase 2 | |
Completed |
NCT03199612 -
Sildenafil To Prevent Clot
|
Early Phase 1 | |
Completed |
NCT02711332 -
Investigating the Influence of Haemolysis on the Potassium Concentration After Capillary Blood Sampling
|
N/A |