Hemoglobins Clinical Trial
Official title:
Comparison of the Automatized and the Optimized Carbon Monoxid Rebreathing Protocol Determining Hemoglobinmass With Capillary and Venous Blood Sampling
The aim of this study is the comparison of two measurement protocols determining hemoglobin mass with two different blood sampling strategies.Both protocols are based on the principle of the carbonmonoxid (CO) rebreathing method. During this measurement, CO is inhaled for a specific time period by the subject in a closed circuit and it is used as a marker to tag circulating hemoglobin.
The optimized CO rebreathing protocol (oCO) will be compared against the automatized CO
rebreathing protocol (aCO). Although theses two protocols using the same method, they show
some relevant differences.
The oCO use a 2 minutes rebreathing period in a seated position and capillary blood is taken.
The aCO use a 10 minutes rebreathing period in a supine position and venous blood samples are
taken.
It is essential to know to what extent the aCO with capillary or venous blood sampling with
different rebreathing time and position compared to oCO will influence the provided
hemoglobin mass values. It is important to ensure the comparability of formely hemoglobinmass
data measured using oCO with hemoglobinmass data measured using aCO for scientific research.
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