The Cold Fluids Study

Status Completed

Clinical Trial Summary

In this single center crossover study the aim is to investigate the effect of Ringer's lactate solution at high and low temperatures on physiological response in healthy adults.18 healthy volunteers will be included. Inclusion criteria is; Age between 18-64. Exclusion criteria is; Pre-existing medical problems, Pregnancy (validated through a certified pregnancy test), Body mass index >35 kg/m2, Medication use apart from allergy medication, contraceptives, or non-steroidal anti-inflammatory drugs. Participants will be randomized to receive 30 ml/kg of Ringer's lactate either cold (15°C, 59°F), or at body temperature (37°C, 98.6°F) during a 30-minute interval. Fluids will be administered through a peripheral vein. After a minimum "washout period" of 24 hours, subjects are switched to receive infusion at the other aforementioned temperatures. Primary outcome is - The increase in MAP at 15 minutes after infusion of the fluid bolus. Secondary outcome is - Time until return of MAP to baseline value after infusion.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Hemodynamic Instability

Clinical Trial Details

NCT number	NCT05610254
Study type	Interventional
Source	Hospital of South West Jutland
Contact
Status	Completed
Phase	Phase 4
Start date	October 24, 2022
Completion date	December 3, 2022

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