Clinical Trials Logo
  1. Home
  2. Hemodynamic Instability
  3. NCT05102058
  4. Details
NCT05102058 Clinical Trial

Magnesium and Dexmedetomidine in Pheochromocytoma

Hemodynamic Instability Clinical Trial

Official title:
Magnesium and Dexmedetomidine Combination Reduces Sodium Nitroprusside Requirement in Laparoscopic Pheochromocytoma

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT05102058
Other study ID # 2021/42
Secondary ID
Status Completed
Phase
First received
Last updated
Start date January 1, 2011
Est. completion date March 1, 2020

Study information
Verified date October 2021
Source Istanbul University
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

Anesthesia management of pheochromocytoma excision surgery is associated with severe hemodynamic fluctuations.The objective of this study was to compare the hypertensive episodes requiring sodium nitroprusside administration between the group treated with magnesium-dexmedetomidine and conventional group in pheochromocytoma.

Recruitment information / eligibility
Status Completed
Enrollment 108
Est. completion date March 1, 2020
Est. primary completion date March 1, 2020
Accepts healthy volunteers No
Gender All
Age group 18 Years to 75 Years
Eligibility Inclusion Criteria: - American Society of Anesthesiologists classification (ASA) 1-3 - high urinary catecholamine or metabolites - tumor sizes < 5 cm - body mass index (BMI) <35 kg/m2 Exclusion Criteria: - open surgery - bilateral masses - tumor larger than 5 cm - incomplete data

Study Design

Related Conditions & MeSH terms

Intervention

Drug:
• Magnesium-Dexmedetomidine
Received oral 300 mg magnesium one week before surgery and magnesium-dexmedetomidine combination perioperatively

Locations
Country Name City State
n/a

Sponsors (1)
Lead Sponsor Collaborator
Istanbul University

Outcome
Type Measure Description Time frame Safety issue
Primary Sodium nitroprusside (SNP) requirement intraoperative hypertensive episodes requiring SNP therapy intraoperative period
Secondary vasoactive therapy hemodynamic fluctuations (hypotension, tachycardia, severe hypertensive crisis) which needed vasoactive therapy. intraoperative period
See also
  Status Clinical Trial Phase
Completed NCT03653910 - Effect-site Concentration of Remifentanil for Double-lumen Tubes Intubation: Airtraq VS Macintosh Laryngoscope N/A
Completed NCT06000098 - Consol Time and Acute Kidney Injury in Robotic-assisted Prostatectomy
Recruiting NCT02565251 - Volemic Resuscitation in Sepsis and Septic Shock N/A
Terminated NCT02365688 - Hemodynamic Response During Goal Directed Fluid Therapy in the OR N/A
Completed NCT01559675 - Trial Comparing Low Dose and High Dose Steroids in Patients Undergoing Colorectal Surgery N/A
Completed NCT01605279 - Dobutamine Versus Placebo for Low Superior Vena Cava Flow in Newborns Phase 2
Recruiting NCT04010058 - Postoperative Continuous Non-invasive Haemodynamic Monitoring on the Ward N/A
Completed NCT06268275 - Comparison of Effects of Scalp Block and Intravenous Esmolol on Hemodynamic Response Following the Skull Pins Application for Elective Supratentorial Craniotomy N/A
Recruiting NCT04926220 - Dynamic Estimation of Cardiac Output in the Operating Room
Not yet recruiting NCT05003011 - Correlation of Hemodynamics Via Pulmonary Artery Catherization and the Cardiospire
Completed NCT03599440 - Effect of Extended Infusion Lines on Pulse Contour-based Measurements
Completed NCT05035485 - Maternal Cardiac Output Response to Rescue Norepinephrine and Phenylephrine Boluses in Patients With Severe Preeclampsia N/A
Not yet recruiting NCT04227821 - Hemodynamic Optimalization in Pediatric Patients
Completed NCT05481047 - Prevention or Treatment of Arterial Hypotension and Oxygen Cerebral Saturation During Major Abdominal Surgery N/A
Completed NCT06158165 - Evaluating The Cardiovascular Effects of Tourniquet Application
Not yet recruiting NCT04076709 - Cardiovascular Effects of Muscle Relaxation During Laparoscopic Surgery Phase 4
Not yet recruiting NCT03828032 - Multi-parameters'Change Process During Dehydration Therapy on Brain Edema Patients. N/A
Completed NCT04089098 - VOLume and Vasopressor Therapy in Patients With Hemodynamic instAbility
Recruiting NCT05570682 - Manually Controlled Infusion vs Target Controlled Infusion for StrokeThrombectomy N/A
Completed NCT04574908 - A Pilot Trial of Continuous Portable Postoperative Hemodynamic And Saturation Monitoring On Hospital Wards N/A