Hemodynamic Instability Clinical Trial
Official title:
Non-invasive Objective Assessment of Hemodynamics in Preterm Neonates - the NOAH Study
Study type: Prospective Observational trial Study design: Longitudinal Population: Preterm newborns <32 weeks gestational age Hypothesis: The inclusion of non-invasive physiological measures of cardiac output, peripheral perfusion and brain oxygenation (NIRS) for preterm neonates is feasible and reveals additional information on the hemodynamic status compared to blood pressure alone. These measurements can improve the ability to rapidly identify those infants who might benefit from intervention and are correlated with short term clinical outcomes.
Understanding neonatal hemodynamics is key to neonatal care. Despite decades of research, uncertainty continues as to how best assess impaired hemodynamics. Hypotension defined by a low Mean Arterial Blood Pressure (MABP) remains a common issue in preterm infants, affecting up to 30% of extremely preterm infants. It is common to focus only on MABP thus neglecting the complex and dynamic (patho)physiology that may be present in newborn infants. Providing sufficient cellular oxygenation is the primary task of the circulatory system and different factors may compromise it. In this prospective observational study the investigators will examine various forms of objective non-invasive continuous hemodynamic monitoring methods in very preterm infants 1. For feasibility of non-invasive CO measurement (first 20 patients) 2. For reproducibility and correlation of this measurement and ECHOcardiography (first 40 echocardiographic examinations) 3. For prediction of therapy response. 4. For correlation with clinical definitions of hypotension/hypoperfusion 5. For prediction of later clinical problems/complications of prematurity and impaired hemodynamic status. ;
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT03653910 -
Effect-site Concentration of Remifentanil for Double-lumen Tubes Intubation: Airtraq VS Macintosh Laryngoscope
|
N/A | |
Completed |
NCT06000098 -
Consol Time and Acute Kidney Injury in Robotic-assisted Prostatectomy
|
||
Recruiting |
NCT02565251 -
Volemic Resuscitation in Sepsis and Septic Shock
|
N/A | |
Terminated |
NCT02365688 -
Hemodynamic Response During Goal Directed Fluid Therapy in the OR
|
N/A | |
Completed |
NCT01559675 -
Trial Comparing Low Dose and High Dose Steroids in Patients Undergoing Colorectal Surgery
|
N/A | |
Completed |
NCT01605279 -
Dobutamine Versus Placebo for Low Superior Vena Cava Flow in Newborns
|
Phase 2 | |
Recruiting |
NCT04010058 -
Postoperative Continuous Non-invasive Haemodynamic Monitoring on the Ward
|
N/A | |
Completed |
NCT06268275 -
Comparison of Effects of Scalp Block and Intravenous Esmolol on Hemodynamic Response Following the Skull Pins Application for Elective Supratentorial Craniotomy
|
N/A | |
Recruiting |
NCT04926220 -
Dynamic Estimation of Cardiac Output in the Operating Room
|
||
Not yet recruiting |
NCT05003011 -
Correlation of Hemodynamics Via Pulmonary Artery Catherization and the Cardiospire
|
||
Completed |
NCT03599440 -
Effect of Extended Infusion Lines on Pulse Contour-based Measurements
|
||
Completed |
NCT05035485 -
Maternal Cardiac Output Response to Rescue Norepinephrine and Phenylephrine Boluses in Patients With Severe Preeclampsia
|
N/A | |
Not yet recruiting |
NCT04227821 -
Hemodynamic Optimalization in Pediatric Patients
|
||
Completed |
NCT06158165 -
Evaluating The Cardiovascular Effects of Tourniquet Application
|
||
Completed |
NCT05481047 -
Prevention or Treatment of Arterial Hypotension and Oxygen Cerebral Saturation During Major Abdominal Surgery
|
N/A | |
Not yet recruiting |
NCT04076709 -
Cardiovascular Effects of Muscle Relaxation During Laparoscopic Surgery
|
Phase 4 | |
Completed |
NCT04089098 -
VOLume and Vasopressor Therapy in Patients With Hemodynamic instAbility
|
||
Not yet recruiting |
NCT03828032 -
Multi-parameters'Change Process During Dehydration Therapy on Brain Edema Patients.
|
N/A | |
Recruiting |
NCT05570682 -
Manually Controlled Infusion vs Target Controlled Infusion for StrokeThrombectomy
|
N/A | |
Completed |
NCT04574908 -
A Pilot Trial of Continuous Portable Postoperative Hemodynamic And Saturation Monitoring On Hospital Wards
|
N/A |