Hemodynamic Instability Clinical Trial
Official title:
The Effects of Esmolol on the Hemodynamic Response to Orotracheal Extubation: a Prospective, Randomized, Double-blind and Placebo-controlled Trial
Beta-blockers are useful tools for the prevention of hemodynamic instability in the manipulation of airways. The main objective of the present study is to evaluate the effectiveness of using esmolol in attenuating hemodynamic responses at the time of tracheal extubation, by assessing the incidence of tachycardia in relation to placebo.
Status | Recruiting |
Enrollment | 80 |
Est. completion date | July 2020 |
Est. primary completion date | July 2020 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years to 60 Years |
Eligibility |
Inclusion Criteria: - Patients aged between 18 and 60 years, electively scaled for surgery requiring general anesthesia. - Physical State 1, 2 or 3 of the American Society of Anesthesiology (ASA) Exclusion Criteria: - Patients with cardiac disease - Patients with renal disease - Patients with liver disease - Patient with lung disease - Patients using beta blockers or calcium channel blockers - Patients who refuse to participate in the study after presenting the informed consent form |
Country | Name | City | State |
---|---|---|---|
Brazil | Hospital de Base do Distrito Federal | Brasília | DF |
Lead Sponsor | Collaborator |
---|---|
Hospital de Base |
Brazil,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Number of participants with adverse events as tachycardia | Intraoperative hemodynamic stability analysis through the incidence tachycardia | Through study completion, an average of 15 minutes (during awakening from anesthesia) |
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