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Patient Management During Major Abdominal Surgery: an Oxygen Consumption Protocol Compared to Standard Approach — HEART-CORE  

Hemodynamic Instability Clinical Trial

Official title:
Patient Management During Major Abdominal Surgery: the Impact of a Hemodynamic Approach Oriented to Oxygen Consumption Optimization Compared to Standard Approach Targeting Preload-dependency and a Clinically-guided Strategy

Clinical Trial Summary

This study compares the actual standard of care with a new protocol to guide hemodynamic optimization during major abdominal surgery, which is more tailored on patient real needs. During general anesthesia metabolic needs of the body are markedly reduced and increase in CO may not be necessary. In addition, excessive fluid administration has been related to worse post-operative outcomes. We divide patients into three groups: the standard treatment group, the NICE protocol group and the intervention group. In this group we use the v-aCO2/CaO2-CvO2 as marker of tissue ability to increase their oxygen consumption in response to increased O2 delivery, and based on this index the administration of fluid. The principal aim is to optimize functional hemodynamics in order to reduce the fluid balance at the end of the surgery.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03113435
Study type Interventional
Source Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Contact Antonio M Dell'Anna, MD
Phone +390630154490
Email anthosdel@yahoo.it
Status Recruiting
Phase N/A
Start date June 1, 2018
Completion date December 31, 2024
View Details
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