Clinical Trials Logo
  1. Home
  2. Hemodialysis Patients
  3. NCT05169125

Reducing Dialysate Sodium Effect on Blood Pressure Variability in Hemodialysis Patients

Hemodialysis Patients Clinical Trial

Official title:
Effect of Reducing Dialysate Sodium Concentration on Blood Pressure Variability in Hemodialysis Patients: A Randomized Controlled Trial

Clinical Trial Summary

In this study the investigators aim to test the effect of lowering dialysate sodium concentration on visit-to-visit blood pressure variability in hemodialysis patients who have achieved their dry weight.

Clinical Trial Description

Cardiovascular diseases are considered the major cause of mortality in maintenance hemodialysis patients. Nevertheless, hypertension is recognized as an important modifiable risk factor for cardiovascular disease among hemodialysis (HD) patients. Apart from blood pressure levels, BP variability, which reflects the fluctuation in BP, has been described as an independent risk factor that linearly associated with all-cause and cardiovascular mortality in HD patients. BPV is categorized as either long or short term, based on the time interval over which it is considered. In the dialysis population, long-term BPV is typically defined on the basis of BP measurements taken at the start of each thrice-weekly hemodialysis treatment (interdialytic BPV). On the other hand, short-term BPV among dialysis patients can be considered in terms of variability that occurs during hemodialysis treatments (intradialytic BPV). Researchers believed that the mitigation strategies of BPV must be paid attention to. Sodium load is associated with thirst, fluid retention, interdialysis weight gain and hypertension for hemodialysis patients, therefore the Kidney Disease Outcomes Quality Initiative (KDOQI) Clinical Practice Guideline highlighted the importance of limiting sodium intake and adequate sodium removal which is considered one of the most important goals of the dialysis therapy. Interestingly, a recent study showed that mild decrease in dialysate sodium concentration could improve systolic blood pressure variability in HD patients at their dry weight, thus improving blood pressure complications and subsequent complications. However, whether improving sodium balance could potentially contribute to better BPV management in HD patients has not been assessed in a randomized manner. Therefore, this study aims to investigate whether lowering dialysate sodium concentration could help mitigate long term (interdialytic) BPV in hemodialysis patients in a randomized controlled manner. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05169125
Study type Interventional
Source Mansoura University
Contact Ghada El-said, Ass. Prof.
Phone 01019080448
Email ghadaalsaid222@gmail.com
Status Not yet recruiting
Phase N/A
Start date January 2022
Completion date July 2022
View Details
See also
  Status Clinical Trial Phase
Active, not recruiting NCT06382701 - Effect of Aromatherapy on Pain, Anxiety and Satisfaction in Cannulation N/A
Completed NCT04674930 - Effects of Exercise Program on Physical Functioning of Hemodialysis Patients. N/A
Recruiting NCT02245633 - Correlation Between Vitamin D Levels to ADAMTS13 , VWF and Micro RNA Expression in Diabetic Hemodialysis Patients N/A
Recruiting NCT01970280 - Low Molecular Weight Heparin in Prevention of Recurrent Arteriovenous Graft Thrombosis in Chronic Hemodialysis Patients. Phase 4
Completed NCT06165211 - Nature-Based Sound Application For Hemodialysis Patients N/A
Completed NCT06106763 - Mandala Colouring On Anxiety, Depression, Pain And Quality of Life N/A
Completed NCT05693584 - The Effect of Using Virtual Reality Glasses on Pain During Fistula Cannulation in Hemodialysis Patients N/A
Completed NCT01932853 - Association Between Dose Dialysis by Kt and Mortality N/A
Completed NCT01273974 - The Immunogenicity of Intradermal Influenza Vaccination in Hemodialysis Patients Phase 2/Phase 3
Completed NCT04139759 - THE EFFECT OF HAND AND FOOT MASSAGE ON FATIGUE IN HEMODIALYSIS PATIENTS N/A
Not yet recruiting NCT05574595 - Effect on Pain and Comfort Associated With Fistula Puncture N/A
Completed NCT04175652 - Effects of Laughter Yoga on Hemodialysis Patients' Plasma-Beta Endorphin Levels, Pain Levels and Sleep Quality N/A
Not yet recruiting NCT06314243 - The Impact of Pumpkin Seed Oil Supplementation on Hemodialysis Patients Phase 3
Completed NCT01596842 - Effect of Omega-3 Fatty Acid on Vitamin D Activation Phase 4
Enrolling by invitation NCT01896882 - Dietary Sodium Restriction in Hemodialysis Patients N/A
Completed NCT00638300 - Removal of Ligand-bound Iron During Intravenous (IV) Iron Administration in Hemodialysis (HD) N/A
Terminated NCT00259714 - Dialysate Sodium Individualization in Hemodialysis Phase 1
Completed NCT01846754 - Prevalence of Fatigue in Hemodialysis Patients N/A
Completed NCT00491868 - Clinical Study of R744 to Hemodialysis Patients Phase 3
Not yet recruiting NCT06449105 - The Effect of Mindfulness Compassionate Living Practice on Hemodialysis Patients N/A