Hemodialysis Patients Clinical Trial
Official title:
Prevalence of Fatigue and Its Related Factors in Hemodialysis Patients
Verified date | April 2014 |
Source | National Taiwan University Hospital |
Contact | n/a |
Is FDA regulated | No |
Health authority | Taiwan: Department of Health |
Study type | Observational |
The prevalence of end stage renal disease in Taiwan was listed first all over the world.
Fatigue, which makes patients unable to be competitive to play their functional roles, is
one of the most bothersome symptoms of patients receiving long-term hemodialysis. Tracing
back to the development of its relating studies, there is no accurate reason that why does
people undergoing hemodialysis feel fatigued. Conclusive predictors of fatigue are still not
shown up yet. Paper review indicated that the level of L-Carnitine concentration, which
affect metabolism of fatty acid, had correlation with fatigue and muscle strength in this
population. The serum concentration of L-Carnitine is influenced a lot by hemodialysis. When
there is deficiency of energy supply, it resulted to decline of muscle strength, which
increased frequency and intensity of fatigue. Hence, the purposes of this study are (1) to
understand the basic condition of fatigue level, muscle and metabolism of fat and
carbohydrate among hemodialysis patients, (2) to analyze correlation among muscle strength,
metabolism of fat/carbohydrate, and fatigue, and (3) to understand correlations among
demographic characteristics, blood test data (hemoglobin, albumin, Kt/V, urea reduction
ratio(URR), blood urea nitrogen(BUN), creatinine, calcium, phosphorus, and C-reactive
protein), mental and social conditions (depression, anxiety, and social support), muscle
strength and fatigue, seeking further exploring predictors of muscle strength and fatigue.
The study use cross-sectional descriptive correlative design with consecutive sampling.
Recruit patients from a hemodialysis unit in a medical center in north Taiwan after
informed- consent. The estimated sample size is 100. To understand relationship among muscle
strength, by-products of fatty acid and carbohydrate and fatigue, we collect data by
measuring their muscle strength (handgrip and 30 seconds sit-to-stand), and analyzing blood
test data and the structured questionnaires which included mental/social data (depression,
anxiety, social support and fatigue level). Descriptive statistics, ANOVA, Pearson's
correlation, Spearsman's rank correlation and stepwise regression were used to analyze the
collected data. Hope this research can get advance in comprehension of cause of fatigue and
improve the fatigue symptom of hemodialysis patients.
Status | Completed |
Enrollment | 88 |
Est. completion date | July 2013 |
Est. primary completion date | July 2013 |
Accepts healthy volunteers | No |
Gender | Both |
Age group | 20 Years to 90 Years |
Eligibility |
Inclusion Criteria: - 1.Hemodialysis Patients 2.Aged above 20 3.Consciousness: oriented Exclusion Criteria: - 1. Unable to complete muscle strength test or questionnaire |
Observational Model: Cohort, Time Perspective: Prospective
Country | Name | City | State |
---|---|---|---|
Taiwan | National Taiwan University Hospital | Taipei |
Lead Sponsor | Collaborator |
---|---|
National Taiwan University Hospital |
Taiwan,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Relationships Among Fatigue, Muscle Power and Metabolomics | 1-year study | No |
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