Hemodialysis Patients Clinical Trial
Official title:
The Comparison of Serum Antibody Response to Standard Intramuscular and Half Dose Intradermal Influenza Vaccine in Hemodialysis Patients in Shiraz City in 1388.
The purpose of this study is to determine whether half-dose intradermal influenza vaccine is as immunogenic as standard dose intramuscular vaccine in hemodialysis patients.
Hemodialysis patients are at high risk of influenza infection due to suppress immune
status.It is recommended to immunize them against influenza annually.in intradermal
vaccination antigens directly present to the large numbers of antigen-presenting cells in
the skin and it may cause greater immunogenicity than in the intramuscular method.
Reduced-dose intradermal influenza vaccine is immunogenic in healthy adult, patients with
solid cancer and three groups of immunocompromized patients including Rheumatologic patients
treated with anti-TNF, HIV-infected and stem cell transplanted patients.
In this study we compare the efficacy of influenza vaccines in half dose intradermal and
standard intramuscular methods among hemodialysis patients.
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Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Prevention
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