NCT03090711 - Clinical Trial References

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

Citation(s)

Cazzoli D, Müri RM, Schumacher R, von Arx S, Chaves S, Gutbrod K, Bohlhalter S, Bauer D, Vanbellingen T, Bertschi M, Kipfer S, Rosenthal CR, Kennard C, Bassetti CL, Nyffeler T
Theta burst stimulation reduces disability during the activities of daily livi
Huang YZ, Edwards MJ, Rounis E, Bhatia KP, Rothwell JC
Theta burst stimulation of the human motor cortex. Neuron. 2005 Jan 20;45(2):201-6.
Marshall L, Helgadóttir H, Mölle M, Born J
Boosting slow oscillations during sleep potentiates memory. Nature. 2006 Nov 30;444(7119):610-3. Epub 2006 Nov 5.
Nyffeler T, Wurtz P, Lüscher HR, Hess CW, Senn W, Pflugshaupt T, von Wartburg R, Lüthi M, Müri RM
Repetitive TMS over the human oculomotor cortex: comparison of 1-Hz and theta burst stimulation. Neurosci Lett. 2006 Nov 27;409(1):57-60. Epub 2006 Oct 17.

Sleep as a Model to Understand and Manipulate Cortical Activity in Order to Promote Neuroplasticity and Functional Recovery After Stroke

Clinical trial NCT03090711 - References