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Hematuria clinical trials

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NCT ID: NCT06299683 Recruiting - Clinical trials for Interstitial Cystitis

Pain Type and Interstitial Cystitis/Bladder Pain Syndrome Treatment

Start date: May 1, 2024
Phase: N/A
Study type: Interventional

Interstitial cystitis/bladder pain syndrome (IC/BPS) is a severe pain condition affecting 3-8 million people in the United States lacking treatments that work. Emotional suffering is common in IC/BPS and known to make physical symptoms worse, and studies show patient sub-groups respond differently to treatment. Individuals with IC/BPS have distinct subgroups, or "phenotypes," largely characterized by the distribution of pain throughout the body. Supported by our preliminary evidence, the overall goal of this project is to assess how IC/BPS phenotype may affect response to two different therapies often given without regard to patient phenotype, pelvic floor physical therapy (PT) and cognitive-behavioral therapy (CBT) for IC/BPS.

NCT ID: NCT06109857 Recruiting - Hematuria Clinical Trials

Bladder Bank (a Prospective Banking Study)

Start date: July 6, 2022
Phase:
Study type: Observational

This study collects blood and urine samples from patients with bladder cancer to support the development of tests for early detection of bladder cancer.

NCT ID: NCT06026189 Recruiting - Bladder Cancer Clinical Trials

Safely Reduce Cystoscopic Evaluations for Hematuria Patients

SeARCH
Start date: May 31, 2023
Phase: N/A
Study type: Interventional

The SeARCH-trial assess the clinical impact of a molecular urine test as a 'urine-first' strategy in the diagnostic workup of patients presenting with microscopic hematuria.

NCT ID: NCT05889195 Recruiting - Clinical trials for Urothelial Carcinoma

Detection and Risk Stratification in Veterans Presenting With Microscopic Hematuria

microDRIVE
Start date: November 2, 2023
Phase:
Study type: Observational

It is of current debate whether the use of invasive (referring to a process that requires insertion into the body) standard of care procedures such as a cystoscopy which is a procedure to look inside the bladder using a thin camera called a cystoscope, is appropriate for use in patients with microscopic hematuria or blood in urine invisible to the naked eye. This is because the risk of disease (bladder cancer - urothelial carcinoma) is relatively low in this population group, approximately 3%. Invasive procedures such as a cystoscopy comes with anxiety and pain, in addition to other potential side effects. This has resulted in low admittance in urology clinics for cystoscopy with hematuria (blood in urine) patients. Therefore, there is a need for a more simple, non-invasive test that can accurately detect the presence or absence of disease (urothelial carcinoma) in patients with microscopic hematuria. There is a potential role Cxbladder, a non-invasive, urine based test, can fill this role.

NCT ID: NCT05646485 Recruiting - Smoking Cessation Clinical Trials

Bladder Cancer Screening Trial

Start date: May 5, 2023
Phase: N/A
Study type: Interventional

There is currently no accepted screening strategy for patients at high risk of developing bladder cancer. This study will ask patients to complete a urine test every 6 months for 2 years to help assess if routine screening helps finding bladder cancer at an earlier stage.

NCT ID: NCT05620784 Recruiting - BPH Clinical Trials

Intra-operative Loop Diuretics to Improve Same-day Discharge Rates After HoLEP

Start date: March 1, 2023
Phase: Phase 3
Study type: Interventional

Holmium Laser Enucleation of the Prostate (HoLEP) is a size-independent treatment option for benign prostatic hypertrophy (BPH) as recommended by the American Urological Association (AUA) Guidelines. Loop diuretics (furosemide) have been given historically during the morcellation portion of HoLEP to promote urine production in the post-operative setting and to minimize the impact of fluid absorption during long periods of morcellation. The intra-operative use of 20mg IV furosemide in perioperative HoLEP pathways has been propagated with the dissemination of HoLEP across North America without evidence to support its routine administration. With increasing surgical efficiency from improvements in laser and morcellator technology, the role of intra-operative furosemide is unknown. This study is designed to assess if there is a significant difference in same day discharge rates after Holmium Laser Enucleation of the Prostate (HoLEP) with and without IV furosemide. .

NCT ID: NCT05415865 Recruiting - Overactive Bladder Clinical Trials

The Effect of Local Anesthetic Solution in the Bladder Prior to Botox Injections in the Bladder

Start date: September 12, 2022
Phase: Phase 3
Study type: Interventional

The purpose of this study is to investigate the effect of Lidocaine solution versus placebo (isotonic Sodium Chloride NaCl) disposed inside the urinary bladder as intravesical anesthesia prior to onabotulinum toxin A injections in the treatment of urgency urinary incontinence.

NCT ID: NCT05220189 Recruiting - Bladder Cancer Clinical Trials

PENK Methylation Test for Detecting Bladder Cancer

Start date: February 3, 2022
Phase:
Study type: Observational

The primary objective of this clinical trial is to determine the sensitivity and specificity of the EarlyTect® Bladder Cancer test for bladder cancer among patients with hematuria by comparing it to the results of cystoscopy examinations. The second objective is to compare the clinical performance of EarlyTect® Bladder Cancer test with a NMP22 test and urine cytology test with respect to bladder cancer. By histopathological examination, lesions identified during cystoscopy will be confirmed as malignant or non-malignant by histological examination.

NCT ID: NCT05207969 Recruiting - Urologic Diseases Clinical Trials

Efficacy of the Act of Urination to Relief the Pain During Flexible Cystoscopy Procedure.

Start date: August 1, 2021
Phase: N/A
Study type: Interventional

This research is about modification during routine cystoscopy (scope in the bladder) procedure [ experimental research ]. The goal of the study is to evaluate patient experience with cystoscopy by using procedural modification to reduce pain perception. The investigator aim for quality improvement of the current methods of cystoscopy to achieve a better patient experience.

NCT ID: NCT05077852 Recruiting - Bladder Cancer Clinical Trials

Intravesical Prostatic Protrusion Mimicking Urothelial Cell Carcinoma of the Bladder

Start date: December 12, 2021
Phase:
Study type: Observational

In this study, investigators aim to determine the true positivity of bladder cancer identified in the bladder base, trigone or neck on ultrasonography (USG) in patients presenting with hematuria or lower urinary tract symptoms, by confirming with the gold standard cystoscopy and biopsy results. It also aims to explore criteria that would allow to differentiate between intravesical prostate protrusion (IPP) due to benign prostatic hyperplasia (BPH) and bladder cancer indicated at the bladder floor, trigone and neck by evaluating false positive results.