Reduced Intensity (RIC) Conditioning And Transplantation of HLA-Haplo-HCT

Status Active, not recruiting

Clinical Trial Summary

This is a single institution phase II study of a reduced intensity conditioning (RIC) followed by a haploidentical hematopoietic cell transplant (haplo-HCT) in persons with diagnosis of hematologic malignancy. Conditioning will consists of fludarabine, cyclophosphamide, melphalan and total body irradiation (TBI) preparative regimen with a melphalan dose reduction for patients ≥55 years old and those with HCT Comorbidity Index (CI) >3. This study uses a two-stage phase II design with accrual goal of 84 patients, using 28 patients separately for arms A, C and D

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT02988466
Study type	Interventional
Source	Masonic Cancer Center, University of Minnesota
Contact
Status	Active, not recruiting
Phase	Phase 2
Start date	January 24, 2017
Completion date	December 2024

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