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Hemangioma clinical trials

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NCT ID: NCT06259292 Recruiting - Clinical trials for GastroIntestinal Bleeding

Comprehensive HHT Outcomes Registry of the United States (CHORUS)

CHORUS
Start date: November 13, 2023
Phase:
Study type: Observational [Patient Registry]

The Comprehensive HHT Outcomes Registry of the United States (CHORUS) is an observational registry of patients diagnosed with Hereditary Hemorrhagic Telangiectasia (HHT). The purpose of this study is to better understand HHT, the symptoms and complications it causes, and the impact the disease has on people's lives. The investigators will collect long-term information about the participant, allowing us to understand how the disease changes over time, and what factors can influence those changes. Ultimately, this should help improve treatments for the disease. Another important goal of the study is to provide a way to contact people to participate in future clinical trials and other research. The registry will be a centralized resource for recruitment for clinical trials. People in the registry will not be obligated to join any of these additional studies, but if interested, can agree to be contacted if they may be eligible for a study. Participants will: - Be asked to provide permission to collect information from their medical records, including things like demographic information, diagnosis information, family history, test results, treatment information, symptoms, complications, lifestyle and other relevant medical information. - Be asked study-related questions by phone or at a clinic visit. - Be asked study-related questions every year after enrollment for up to 10 years or until the study ends. A member of the study team will communicate with participants by phone or at clinic visits to collect information regarding any changes to their health over the previous year/s including new test results, treatment information, symptoms, and complications from HHT.

NCT ID: NCT06214767 Recruiting - Clinical trials for Hemangioma, Cavernous, Central Nervous System

Study on Treatment Decision-Making and Prognostic Follow-Up for Untreated Cerebral Cavernous Malformations

Start date: December 1, 2023
Phase:
Study type: Observational

The goal of this observational study is to evaluate and predict the risk associated with cerebral cavernous malformations (CCMs) using advanced artificial intelligence and radiomics analysis technology. The study focuses on individuals who have been diagnosed with cerebral cavernous malformations (CCMs). Main Questions to Answer: How can AI-based radiomics features predict the risk of complications (such as bleeding or epilepsy) in individuals with CCMs? What are the most reliable imaging and clinical markers for assessing the prognosis of CCMs? Participants will be required to undergo regular medical imaging to gather traditional and radiomics imaging features. Participants will provide clinical data, including past medical history and results of any laboratory tests. Participants will be part of a three-year follow-up observation to monitor the progression or stability of CCMs. Contribution of biological samples for advanced testing might also be requested. This study aims to create an AI-based decision-making tool that will guide clinicians in the management of CCM, with the potential to significantly improve patient outcomes through personalized medical approaches.

NCT ID: NCT06130436 Recruiting - Liver Cancer Clinical Trials

Application of Perioperative Remote Ischemic Conditioning in Patients Undergoing Hepatectomy

Start date: October 25, 2023
Phase: N/A
Study type: Interventional

Our primary aim is to investigate whether perioperative remote ischemic conditioning (PRIC) as an adjunctive treatment can improve postoperative recovery in patients undergoing hepatectomy as an adjunct to standard treatment.

NCT ID: NCT06098872 Recruiting - Clinical trials for Arteriovenous Malformations

Pilot Study on Trametinib for Surgical Unruptured AVMs

Start date: January 30, 2024
Phase: Phase 2
Study type: Interventional

Arteriovenous malformation (AVM) is a tangle of abnormal vessels that can progress through life and cause significant bleeding, deformity, pain, and deficits in day-to-day activities. Surgery is a common treatment option for patients with AVMs where the goal is to safely remove the entire AVM without causing complications. While any surgery has its potential risks, most of the potential modifiable risk factors relate to the AVM's structure, such as the AVM size or presence of high risk structural features seen on scans. The purpose of this pilot study is to see whether taking an oral medication called Trametinib can improve upon the AVM structure in adult patients before their scheduled surgery.

NCT ID: NCT05479123 Recruiting - Clinical trials for Infantile Hemangioma

Assessing the Impact of Dosage Frequency of Propranolol on Sleep Patterns in Patients With Infantile Hemangiomas

Start date: June 23, 2022
Phase: Phase 4
Study type: Interventional

The purpose of this study is to assess the baseline sleep pattern disruption for patients starting oral propranolol at the standard BID dosing regimen compared to the control (timolol) group and to determine if there is a significant improvement in the sleep patterns in infants taking oral propranolol on the TID dosing regimen versus the control (timolol) group

NCT ID: NCT05449106 Recruiting - Clinical trials for Brain Arteriovenous Malformations

Evaluation of Clinical Outcomes of Unruptured bAVMs Treated With Medical Management Alone Based on Multimodal CT

Start date: May 25, 2022
Phase:
Study type: Observational [Patient Registry]

The purpose of this study is to investigate the role of multimodal CT in evaluating and predicting different clinical outcomes in patients with unruptured brain arteriovenous malformations with medical management alone. This study will be undertaken in the following aspects: 1. Morphological, structural and imaging histological signal analysis based on multimodal CT to explore the relationship between imaging features and different clinical outcomes of bAVMs. 2. Hemodynamic and flow pattern analysis of local and peripheral bAVMs based on multimodal CT to explore the association between blood flow features and different clinical outcomes. 3. Based on multimodal CT and deep learning algorithms to create an automated segmentation model for bAVMs and a prediction model for distinct clinical outcomes. The obtained patient information includes: Baseline information, CT, MRI, DSA (Optional), and follow-up information. Follow-up will be undertaken at 6 months, 12 months, 24 months and 36 months after enrollment with the following primary observation. Main observation endpoints: 1. Hemorrhage events associated with bAVMs 2. New epilepsy symptoms or exacerbations 3. New neurological dysfunction(including motor dysfunction, cognitive dysfunction, etc).

NCT ID: NCT05348902 Recruiting - Clinical trials for Locked-In Syndrome;Pulmonary Arteriovenous Malformation

Locked-in Syndrome Caused by Pulmonary Arteriovenous Malformation: A Case Report

Start date: October 1, 2021
Phase:
Study type: Observational

In this case, we report a case of atresia syndrome (LIS), a serious neurological disease caused by pulmonary arteriovenous fistula (PAVM). We present a previously healthy middle-aged woman who developed atresia syndrome after severe pontine infarction due to basilar artery occlusion due to undiagnosed arteriovenous malformation. This report reviewed the medical history, post-admission examination and related literature, and concluded that PAVM should be considered as the cause of implicit stroke, especially in young patients with right-to-left shunt, and should be actively treated.

NCT ID: NCT05187923 Recruiting - Clinical trials for Infantile Hemangiomas

Computer Aided Tool for Diagnosis of Neck Masses in Children

Start date: January 1, 2021
Phase:
Study type: Observational

The aim of this study was to evaluate the diagnostic efficacy of computer aided diagnostic tool for neck masses using machine learning and deep learning techniques on clinical information and radiological images in children.

NCT ID: NCT05125471 Recruiting - Clinical trials for Arteriovenous Malformations (Extracranial)

Cobimetinib In Extracranial Arteriovenous Malformations (COBI-AVM Study)

Start date: July 26, 2022
Phase: Phase 2
Study type: Interventional

The purpose of this open-label study is to evaluate the safety and efficacy of cobimetinib in extracranial AVM.

NCT ID: NCT05058482 Recruiting - Clinical trials for Intracranial Arteriovenous Malformations

Non-adhesive Liquid Embolic System in the Embolization of Cerebral Arteriovenous Malformations

Start date: December 2, 2021
Phase: N/A
Study type: Interventional

This clinical trial is to verify the safety and effectiveness of the Non-adhesive Liquid Embolic System(NALES) produced by Suzhou Hengrui Hongyuan Medical Technology Co., Ltd. in the process of clinical use to support the application of the National Medical Products Administration ( NMPA) product registration approval.