Study of Risk Factors for the Occurrence and Severity of Exertional Heatstroke in the Military Environment — EXPLO-CCE  

Heat Stroke Clinical Trial

Official title: Study of Risk Factors for the Occurrence and Severity of Exertional Heatstroke in the Military Environment

Status Recruiting

Clinical Trial Summary

Although the circumstances of onset and management of exertional heatstroke have been identified for several years, its pathophysiology remains imperfectly understood. Exertional heatstroke is the result of both extrinsic (i.e. environmental) and intrinsic (i.e. individual) contributing factors.

Extrinsic factors are well known (high ambient temperature and hygrometry, poorly "breathable" clothing, intense and prolonged physical effort) but some of them may be observed in milder conditions. In the French Armed Forces, 25% of the exertional heatstrokes that have been reported between 2005 and 2011 occurred below 17°C.

Intrinsic factors, on the other hand, are numerous and less consensual, partly because of the imperfect knowledge of exertional heatstroke physiopathology. Potential factors include a thermoregulatory defect (inability to maintain a temperature plateau during an effort) and several genetic mutations may also contribute to explain a propensity to present an exertional heatstroke. While exertional heatstroke is clearly not a monogenic pathology, the association of several polymorphisms could contribute to this vulnerability. Among the genes that have been explored, mutations in ryanodine receptor type 1 (RyR 1), calsequestrin-1 or angiotensin-1 converting enzyme (ACE) appear to be potential candidates. However, it is very likely that other polymorphisms may be involved, such as: genes involved in sports performance and exercise rhabdomyolysis, in the inflammatory cascade, permeability of the digestive epithelial barrier, adenosine receptors and susceptibility to anxiety.

Finally, motivation is a mixed factor often claimed to be involved in exertional heatstroke but has never been quantified and needs to be objectified.

To date, none of these hypotheses has been clearly assessed by comparing patients who experienced exertional heatstroke to healthy subjects.

Clinical Trial Description

n/a

Related Conditions & MeSH terms

• Heat Stroke

• NCT number: NCT04593316
• Study type: Observational
• Source: Direction Centrale du Service de Santé des Armées
• Contact: Arnaud-Xavier JOUVION, MD
• Phone: 491617679
• Email: arnaud-xavier.jouvion@intradef.gouv.fr
• Status: Recruiting
• Start date: November 2, 2020
• Completion date: November 2024