Heart Transplantation Clinical Trial
Official title:
Characterization of Brachial Arterial t-PA Release, Vasodilator Function, and Vascular Compliance and Correlation With Fibrinolytic Balance, Oxidative Stress, and Inflammation Measures in Heart Transplant Recipients (SCCOR Project 1, Aim 3C)
Bradykinin stimulates t-PA release from intact vessels, but not from endothelial cells in
culture. It has been proposed that the nerves of blood vessels are the source of bradykinin
stimulated t-PA release. In order tho test this hypothesis, we intend to infuse bradykinin
into the brachial (arm) artery and the coronary arteries of heart transplant recipients and
control subjects. This is because heart transplant recipients do not have nerves to their
coronary arteries.
This protocol studies the effects of bradykinin on t-PA release in the forearm of transplant
recipients. The brachial artery has intact nerves.
Separate protocols address coronary artery infusions in healthy subjects and transplant
recipients and forearm infusions in healthy subjects.
n/a
Allocation: Non-Randomized, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Basic Science
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