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Heart Transplantation clinical trials

View clinical trials related to Heart Transplantation.

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NCT ID: NCT06032195 Active, not recruiting - Clinical trials for Heart Transplantation

Study of Organ Perfusion in Heart Transplantation in Children

Start date: August 15, 2023
Phase: Phase 2
Study type: Interventional

The goal of this prospective randomized single blind multicenter phase II study is to compare organ perfusion with Custodiol-N and Custodiol in heart transplantation in children of all ages (birth to <18 years) being listed on the waiting list for heart transplantation. The main question it aims to answer is: to compare the safety of Custodiol-N in heart transplantation in children in comparison to its precursor product Custodiol. Participants will receive either a heart to be transplanted, either perfused with Custodiol-N or Custodiol to Researchers will compare the two solutions to see if the new solution Custodiol-N is safe in heart transplantation in children.

NCT ID: NCT03991923 Active, not recruiting - Clinical trials for Heart Transplantation

Non-ischemic Preservation of the Donor Heart in Heart Transplantation

Start date: November 25, 2020
Phase: N/A
Study type: Interventional

The study intends to compare standard ischemic cold static storage (ICSS) of retrieved hearts intended to be transplanted, to non-ischemic heart preservation (NIHP) in a randomized clinical multicentre trial. The primary hypothesis is that the non-ischemic hypothermic cardioplegic preservation (NIHP) is safe and superior to ischemic cold static storage (ICSS) of donor hearts. The study will investigate the safety and superiority of the new methodology in terms of improved immediate and prolonged organ function in adult heart transplanted patients.

NCT ID: NCT03152422 Active, not recruiting - Clinical trials for Heart Transplantation

Urinary Proteomics in Predicting Heart Transplantation Outcomes

uPROPHET
Start date: October 1, 2016
Phase:
Study type: Observational

uPROPHET aims to validate urinary proteomics for risk stratification and monitoring graft performance is recipients of heart transplants

NCT ID: NCT01686191 Active, not recruiting - Clinical trials for Heart Transplantation

Genetic Predictors of Renal Dysfunction Following Heart Transplantation

Start date: August 2012
Phase:
Study type: Observational

Kidney disease is a common problem after heart transplantation. It may be caused by anti-rejection medications such as cyclosporine or tacrolimus. However, the reason why some people develop kidney problems after a heart transplant, but other people do not, is not fully known. This study plans to learn more about the relationship between a person's genetic make-up (DNA; deoxyribonucleic acid) and the risk of kidney problems after a heart transplant. The long-term goal of this research is to identify genetic variations that may help predict the development of kidney problems after heart transplantation.

NCT ID: NCT01608477 Active, not recruiting - Clinical trials for Heart Transplantation

Building Research Initiative Group: Chronic Illness Management and Adherence in Transplantation

BRIGHT
Start date: March 2012
Phase:
Study type: Observational

Over the past decades, survival rates in heart transplantation recipients improved significantly, due to advancements in regimens of immunosuppressives and surgical techniques, but are still limited to the first 12 months post transplantation. Long-term survival remains almost unchanged indicating the need to identify and improve relevant factors. Evidence in other chronically-ill patient populations shows that the healthcare system (e.g. level of chronic illness management (CIM)) and patient self-management (e.g. adherence) drive improvements in outcomes. The BRIGHT study is the first multi-centre, multi-continental study examining healthcare system and heart transplant centres chronic illness management practice patterns and potential correlates of immunosuppressive medication nonadherence. The knowledge gained will inform clinicians, researchers and healthcare policy makers about the level(s) interventions need to be implemented at to improve long-term outcomes for transplant recipients.

NCT ID: NCT01294020 Active, not recruiting - Clinical trials for Kidney Transplantation

Study to Compare the Pharmacokinetics of Tacrolimus in Stable Pediatric Allograft Recipients Converted From Prograf® to Advagraf®

Start date: May 25, 2011
Phase: Phase 2
Study type: Interventional

Parts A & B: Conversion of stable pediatric allograft recipients from Prograf® immunosuppression to Advagraf® immunosuppression to compare exposure and one year follow-up for safety and efficacy. Part C: Continuation of long-term follow-up and provision of ongoing study medication to subjects to whom Advagraf® is currently not available.

NCT ID: NCT00752336 Active, not recruiting - Clinical trials for Heart Transplantation

Prospective Intervention Study to Improve HRQoL and Exercise Tolerance After Heart Transplantation

Ergo-HTx
Start date: January 2002
Phase: N/A
Study type: Interventional

A prospective, interventional rehabilitation program was initiated to improve exercise tolerance and psychosocial functioning in patients after heart transplantation (HTx) and to evaluate long-term effects on health-related quality of life (HRQoL).Study subjects were randomized to either intervention or to control group and were followed with regular cardiopulmonary exercise testings and HRQoL measurements (SF-36) for 36±3 months after HTx. Patient characteristics did not differ concerning age, gender, and diagnosis at study entry. IG patients received regular psychosocial support and performed a home-based supervised ergometer training program. CG patients were recommended to perform regular exercising.

NCT ID: NCT00505102 Active, not recruiting - Kidney Diseases Clinical Trials

Safe Renal Function In Long Term Heart Transplanted Patients

SAREFU
Start date: January 2007
Phase: Phase 4
Study type: Interventional

The purpose of this study is to verify whether the reduction of cyclosporine dosages associated with Everolimus administration may improve renal function as compared to patients maintained on standard immunosuppressive therapy

NCT ID: NCT00421005 Active, not recruiting - Clinical trials for Hypercholesterolemia

Fluvastatin After Heart Transplantation

Start date: November 2004
Phase: Phase 4
Study type: Interventional

Statin therapy is a treatment with a proven positive impact on survival after heart transplantation. However, it is unclear whether the beneficial effect of this class of drugs depends solely on their LDL-lowering properties or on anti-inflammatory and immuno-modulatory properties. Thus, this study was designed to compare safety and efficacy of two different strategies: 1. high fixed statin dose vs. 2. low starting dose with LDL-driven doses adjustments.