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Donor-derived Cell Free DNA as a New Biomarker in Cardiac Acute Rejection — FreeDNA-CAR  

Heart Transplant Rejection Clinical Trial

Official title:
Donor-derived Cell Free DNA as a Potential New Biomarker in Cardiac Transplantation: Role in Acute Rejection

Clinical Trial Summary

FreeDNA-CAR is a prospective, observational multicenter study, that will include a total of 200 adult heart transplant (HT) patients from 14 centers in Spain. Our main objective is to test donor-derived Cell-Free DNA (dd-cfDNA) against endomyocardial biopsy (EMB) for the diagnosis of acute cellular rejection.

Clinical Trial Description

All patients will be enrolled immediately after HT, and will undergo undergo routine surveillance EMB at 15 days, 1 month, 2, 3, 4, 6 and 12 months after HT. Simultaneously with each EMB, dd-cfDNA will be measured in plasma. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04973943
Study type Observational
Source Puerta de Hierro University Hospital
Contact Marta B Jimenez-Blanco Bravo, MD
Phone 0034 637747916
Email martajbb@gmail.com
Status Recruiting
Phase
Start date March 19, 2019
Completion date April 2022
View Details
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